Grants for Nonprofits

Office of the National Coordinator · Amount varies

This is a forecasted Leading Edge Acceleration Projects for Health IT (LEAP) opportunity from the Office of the National Coordinator, which funds development of innovative health information technology to address emerging needs in health data exchange and use. Such awards typically go to organizations with health IT research and development capacity, such as universities, nonprofits, and companies. Eligibility, funding amounts, and deadlines have not yet been published for this cycle.

State Treasurer's Office · $1–$5B

This California Health Facilities Financing Authority program offers tax-exempt bond financing (loans, not grants) to nonprofit 501(c)(3) health facilities and public health facilities such as district hospitals. Applicants must qualify as a health facility under the Authority's Act, have provided the same services for at least three years, and demonstrate fiscal soundness and ability to repay; new organizations are generally not eligible. There is no loan maximum and maturities can run up to about 40 years, with funds usable for construction, acquisition, equipment, refunding prior debt, and related costs, subject to issuance and annual fees.

U.S. Mission to Italy · Amount varies

This is a forecasted Annual Program Statement from the U.S. Mission to Italy's Public Diplomacy Section, which typically funds projects that strengthen U.S.-Italy ties through cultural, educational, media, and exchange programming. Detailed eligibility, funding amounts, and deadlines have not yet been published. Embassy public diplomacy programs are commonly open to nonprofits, NGOs, educational institutions, and individuals, often with a connection to Italy, but specific requirements for this cycle are not yet stated.

Coastal Conservancy · Amount varies

Open to nonprofits, public agencies, and tribal governments, this Coastal Conservancy program funds the planning, design, permitting, and construction of lower-cost overnight coastal accommodations so more Californians, especially low- and middle-income households and underserved communities, can stay at the coast. Award amounts and deadlines are not listed. The program is geographically limited to the California coast and is not open to individuals or for-profit businesses.

State Treasurer's Office · $25K–$1.5M

This California Health Facilities Financing Authority loan program (HELP II), not a grant, offers low-interest loans of $25,000 to $1.5 million to nonprofit 501(c)(3) health facilities that qualify as small (annual gross revenue of $30 million or less), rural, or public health facilities. Applicants must be California-licensed, have operated the same services for at least three years, show fiscal soundness, and contribute a minimum 5% match; funds can cover property purchase/construction, equipment, fees, or refinancing. Interest is 3% (4% for refinancing), and a gross revenue pledge plus a lien is required.

State Treasurer's Office · $1–$50M

This California Health Facilities Financing Authority program (CHFFA) provides tax-exempt equipment financing (a loan, not a grant) to eligible health facilities that are nonprofit 501(c)(3) corporations or public health facilities such as district hospitals. Applicants must have operated the same services for at least three years and demonstrate fiscal soundness; loans start at a $500,000 minimum with no maximum and carry market-rate fixed interest plus application and administrative fees. Three years of audited financial statements are required, and loan maturity is tied to the useful life of the financed equipment.

Department of Commerce · $1–$1.5M

The Department of Commerce / Economic Development Administration Research and National Technical Assistance (RNTA) program funds research and technical assistance projects that support economic development in economically distressed areas of the U.S. Eligibility is broad, including district organizations, tribes, states, local governments, institutions of higher education, nonprofits acting with local officials, private individuals, and for-profit organizations. Awards range up to about $1.5 million, and applications use a two-step process (concept proposal first, then invited full application) submitted through EDA's EDGE platform. No deadline is stated.

U.S. National Science Foundation · Amount varies

This U.S. National Science Foundation program (Particulate and Multiphase Processes) funds fundamental research on the physics and chemistry of particulate and multiphase systems, including suspensions, granular flows, structured and active fluids, aerosols, and self-assembly processes, with relevance to advanced manufacturing, energy, biotechnology, and environmental sustainability. Eligibility is described as unrestricted (open to any entity type), though NSF research awards in practice are typically made to U.S. universities and research organizations. Funding amounts and deadlines are not stated.

State Water Resources Control Board · Amount varies

Open to public agencies (cities, towns, districts, state agencies), Native American tribal governments or organizations with jurisdiction over waste disposal, approved Section 208 management agencies, 501(c)(3) nonprofits, and National Estuary Programs. The California fund provides low-interest financing (and, for small disadvantaged communities, grants or principal forgiveness of up to 50-100%) for publicly owned wastewater, sewer, stormwater, water reclamation, and nonpoint-source pollution projects, with no maximum funding limit and repayment over up to 30 years. Most awards are loans rather than grants, and grant/forgiveness eligibility depends on meeting disadvantaged-community affordability criteria; projects must be in California.

State Water Resources Control Board · Amount varies

California's State Water Resources Control Board uses the Cleanup and Abatement Account (CAA) to fund projects that clean up or abate water pollution where no viable responsible party exists, and to address urgent drinking water needs caused by drought, contamination, or other emergencies. Eligible applicants are nonprofits, public agencies, and tribal governments; individuals and for-profit businesses are not eligible. Projects must address waters of the State of California, and award amounts and deadlines are not specified here.

State Water Resources Control Board · $250K–$500K

Nonprofits, public agencies, and tribal governments can apply to California's State Water Board Drinking Water State Revolving Fund for planning costs of drinking water projects, such as feasibility studies, design documents, environmental review, and rate studies. Small water systems serving disadvantaged or severely disadvantaged communities may receive up to $500,000 in principal forgiveness/grant funds, while other systems may receive subsidized loans. Applications are accepted on a continuous basis and undergo technical, environmental, legal, and financial review; the most favorable terms are limited to qualifying small disadvantaged-community systems.

Centers for Disease Control-GHC · Amount varies

This is a forecasted Centers for Disease Control (Global Health Center) cooperative agreement to improve regional capacity to respond to HIV, tuberculosis, and other global health priorities in Central America. Such awards typically go to organizations with regional public health implementation experience, such as nonprofits, NGOs, universities, and regional or foreign health entities, and are geographically focused on Central America. Eligibility, funding amounts, and deadlines have not yet been published for this cycle.

State Water Resources Control Board · $2M–$10M

Nonprofits, public agencies, and tribal governments operating eligible community water systems may apply to California's Drinking Water State Revolving Fund construction program, which finances drinking-water infrastructure (treatment, sources, storage, distribution). Eligible community water systems may receive principal forgiveness/grant from about $2 million up to 100% of project cost depending on project type and community need, with the remainder as low-interest loans repaid over 30–40 years. Applications are accepted continuously; this is restricted to public water system projects in California.

State Treasurer's Office · $0–$1M

California's PANACEA program provides short-term interim financing (up to $1 million) to charter schools that have a reservation of funds through the Charter School Facilities Program or are awaiting long-term bond financing. Eligibility is limited to nonprofits and public agencies operating qualifying charter schools, so this is narrow and tied to participation in the related state facilities or bond programs. Standard applicants outside the charter school facilities pipeline will not qualify.

State Treasurer's Office · Amount varies

Open to nonprofits and public agencies financing charter school facilities. This California State Treasurer program funds debt-service reserves to help charter schools borrow for acquiring, renovating, building, or refinancing their facilities — it backs the financing rather than paying project costs directly. Award amounts and deadlines aren't specified; the program enhances credit for charter school facility debt.

State Treasurer's Office · $100K–$250K

Charter schools that are nonprofits or public agencies can apply to California's Charter School Revolving Loan Fund for low-cost loans of up to $250,000, with priority for schools opening in the current fiscal year. Note this is a loan (which must be repaid), not a grant. The application period opens and closes on dates announced via the program's listserv, and applicants undergo a credit evaluation.

State Treasurer's Office · Amount varies

Open to nonprofits and public agencies, this California program provides annual grants that offset ongoing facility (rent/lease) costs for charter schools serving a high percentage of students eligible for free or reduced-price meals, or located in comparable school attendance areas. Award amounts and deadlines vary and are announced annually on the CSFA website. Eligibility is narrow: it is limited to qualifying California charter schools rather than general applicants.

Department of Health Care Services · Amount varies

California's Department of Health Care Services funds nonprofit, DHCS-licensed residential substance use disorder facilities to start or expand medication-assisted treatment (MAT) services for opioid and other substance use disorders, with awards scaled by facility size up to roughly $250,000 to $550,000. Only nonprofits operating qualifying licensed SUD facilities are eligible, and facilities must have or be able to obtain Incidental Medical Services certification within six months. Most funding must go toward infrastructure and staffing for treatment, and projects serve California; this opportunity is currently forecasted.

Department of Forestry and Fire Protection · Up to $0

California's Department of Forestry and Fire Protection (CAL FIRE) offers Tribal Wildfire Resilience grants for projects serving California Native American tribes, supporting Traditional Ecological Knowledge, cultural and prescribed burns, forest health and fuels reduction, watershed restoration, and related workforce training. Eligibility is limited to nonprofits and tribal governments; individuals, businesses, and other government agencies are not eligible. This is a forecasted 2026 solicitation, so the deadline and award amounts are not yet finalized.

Wildlife Conservation Board · Amount varies

California's Wildlife Conservation Board Desert Conservation Program is open to nonprofits, public agencies, and tribal governments. It funds land acquisition, habitat restoration, invasive plant removal, seed collection, and scientific studies that protect and restore the Mojave and Colorado Desert regions of California, with pre-applications accepted on a continuous (rolling) basis. No specific award amount or deadline is stated. Projects must be located in the California desert region, so this is geographically limited.