Browse grants

National Institutes of Health · Amount varies

The goal of this NOFO is to support R21 applications for novel theory and methods development that better delineate how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary across the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, simulations, and validation using available large-scale datasets

National Institutes of Health · Amount varies

This Notice of Funding Opportunity (NOFO) for R34 planning grant applications focuses on prevention and intervention strategies for fetal alcohol spectrum disorders (FASD) throughout the lifespan. The intent of this NOFO is to support research that advances (1) prevention approaches to reduce prenatal alcohol exposure and incidence of FASD and (2) interventions for FASD. It is expected that research conducted via this mechanism will consist of studies that are a pre-requisite for preparing and submitting subsequent applications for larger scale FASD prevention or intervention studies. Applicants interested in exploratory phased projects may consider NOFO (TEMP-23833, the R61/R33 option).

National Institutes of Health · Amount varies

The goal of the proposed funding announcement is twofold, to promote preclinical and patient based studies examining the mechanism(s) through which incretin mimetics (including agonists or antagonists of GLP-1, GIP-1, or dual GLP-1/GIP-1 agents) impact cancer risk, and to draw talented scientists who understand the dynamic changes caused by these agents to investigate the mechanisms of how these agents influence cancer risk rather than shorter term outcomes such as weight loss and diabetes. The data thus far suggests that these agents may increase the risk of some, while decreasing the risk of other obesity related cancers.

National Institutes of Health · Amount varies

This NOFO is a call to action in response to the mental health crisis in the United States. We seek applications that will study methods to increase access to evidence-based interventions and services for youth mental health, including those living in rural areas, inner cities, and other under-resourced areas, and youth experiencing housing and food insecurities and out-right homelessness. Applications should address research related to optimizing assessment, intervention and service strategies, overcoming challenges related to the workforce shortage, wait lists for treatment, integration of treatment and preventive interventions into settings where people are most likely to be best identified as needing care (eg: schools, social service, pediatric medicine and justice), and service interventions that address systemic barriers to access and quality of mental health care (structural, policy, organizational, value (cost/financing), management).

National Institutes of Health · Up to $500K

Through this Notice of Funding Opportunity, the National Cancer Institute (NCI) seeks research projects that implement early phase (Phase 0, I, and II) investigator-initiated clinical trials focused on cancer-targeted diagnostic and therapeutic interventions of direct relevance to the research mission of DCTD and OHAM. The proposed project must involve at least 1 clinical trial related to the scientific interests of one or more of the following research programs: Cancer Therapy Evaluation Program, Cancer Imaging Program, Cancer Diagnosis Program, Radiation Research Program, Complementary and Alternative Medicine Program and/or the HIV and AIDS Malignancies Research Programs. Applicants may propose to conduct an early phase trial by itself, or in combination with another research aim(s) as appropriate.

National Institutes of Health · Up to $1.5M

The objective of this funding opportunity is to support investigator-initiated, phase I clinical trials for diagnostic and therapeutic interventions for heart, lung, blood, and sleep (HLBS) disorders in adults and children. The proposed trial can be single or multisite. Applicants applying for funding under this NOFO should be ready to initiate the clinical trial within the first quarter of the project period. Discussion, submission, and attainment of applicable regulatory (FDA, DSMB, IRB) approvals, and establishment of drug (and placebo, if applicable) supplies, and any necessary third-party agreements should be established by the time of award. If time and support for these and other pre-clinical and/or trial readiness activities are desired, applicants should consider the companion NOFO which utilizes an R61/R33 phased approach.

National Institutes of Health · Amount varies

The objective of this funding opportunity is to support investigator-initiated, Phase I clinical trials for diagnostic and therapeutic interventions for heart, lung, blood, and sleep (HLBS) disorders in adults and children. In addition to supporting clinical trial start-up and implementation activities, this FOA will provide support for final stage preclinical activities needed for the implementation of the proposed trial. All the activities proposed in the R61 phase must be directly related to the therapeutic/diagnostic in preparation for the clinical trial. The proposed trial can be single or multisite. This NOFO will utilize a bi-phasic, milestone-driven mechanism of award where the first phase can be used to finalize required pre-trial activities such as stability, shipping studies, and site training.

National Institutes of Health · Amount varies

The goal of the proposed funding announcement is twofold, to promote preclinical and patient based studies examining the mechanism(s) through which incretin mimetics (including agonists or antagonists of GLP-1, GIP-1, or dual GLP-1/GIP-1 agents) impact cancer risk, and to draw talented scientists who understand the dynamic changes caused by these agents to investigate the mechanisms of how these agents influence cancer risk rather than shorter term outcomes such as weight loss and diabetes. The data thus far suggests that these agents may increase the risk of some, while decreasing the risk of other obesity related cancers.

National Institutes of Health · Amount varies

This Notice of Funding Opportunity Announcement (NOFO) intends to supports studies that are both necessary and sufficient to inform the planning of a Phase II-IV clinical trial within NHLBI's mission. The NHLBI expects that applications to this NOFO will describe the planned clinical trial and in so doing demonstrate that the proposed (R34) research is scientifically necessary to design or plan the subsequent trial. Furthermore, this NOFO will support research projects that are designed to provide results that will be sufficient to inform the future trial without further studies. The planned Phase II, III, or IV trial must be primarily intended to test the efficacy, safety, clinical management, or implementation of intervention(s) in the prevention and/or treatment of heart, lung, blood, and sleep disorders. In contrast to the study start up or preparation phase of NHLBI funding opportunities for clinical trials (as described at https://www.nhlbi.nih.gov/grants-and-training/funding-opportunities-and-contacts/clinical-trials-optimization), the R34 mechanism is intended to provide new information that answers a scientific or operational question(s) which may be pragmatic in nature and, therefore, informs the final development of a Phase II-IV clinical trial. Regardless of the results of the R34, support of the proposed future clinical trial will require a new application.

National Institutes of Health · Up to $375K

The purpose of this Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions is to support small scale research grants at institutions that do not receive substantial funding from the NIH, with an emphasis on providing biomedical research experiences primarily for undergraduate students and enhancing the research environment at applicant institutions.Eligible institutions must award baccalaureate science degrees and have received no more than $6 million dollars per year of NIH support (in both direct and F and A/indirect costs) in 4 of the last 7 fiscal years. For institutions composed of multiple schools and colleges, the $6 million funding limit is based on the amount of NIH funding received by all the non-health professional schools and colleges within the institution as a whole.This Notice of Funding Opportunity (NOFO) supports investigator-initiated mechanistic and/or minimal risk clinical trials addressing the mission and research interests of the participating NIH institutes. For the purpose of this NOFO, minimal risk clinical trials are defined as those that do not require FDA oversight, do not intend to formally establish efficacy, and have low risks to potentially cause physical or psychological harm.

National Institutes of Health · Up to $500K

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to stimulate translation of scientific discoveries and engineering developments in imaging, data science and/or spectroscopic technologies into methods or tools that address contemporary problems in understanding the fundamental biology, potential risk of development, diagnosis, treatment, and/or disease status for cancer or other disease.

National Institutes of Health · Up to $250K

The purpose of this Notice of Funding Opportunity (NOFO) is to advance the development of novel informatics and data science approaches that can help individuals understand and improve their health through actionable insights. NLM seeks applications that further the science of personal health informatics by providing meaningful and actionable insights to individuals through innovative personal health data collection, integration, analysis, and personalized risk assessments and interpretation. Applications seeking to advance the understanding of how informatics tools, systems, and platforms can best present the results, interpretation, and limitations of personalized assessments for the benefit of individuals are encouraged. Applications should include end user engaged approaches and real-world evaluation to inform the design of generalizable, reusable, and scalable personal health informatics tools, systems, and platforms for the benefit of individuals in understanding and improving their health.

Office of the Assistant Secretary for Health · $200K–$22M

The Office of Population Affairs (OPA) announces the anticipated availability of funds for Fiscal Year (FY) 2027 grants under the authority of Title X of the Public Health Service Act, Section 1001 (42 U.S.C. §300).This notice solicits applications for projects to provide Title X services throughout the 50 United States, District of Columbia, Guam, the Commonwealth of Puerto Rico, the Northern Mariana Islands, the U.S. Virgin Islands, American Samoa, the U.S. Outlaying Islands (Midway, Wake, et al.), the Republic of the Marshall Islands, the Federated State of Micronesia, and the Republic of Palau (hereafter, States). OPA intends to make available approximately up to $257 million for up to 90 grant awards for a period of up to five (5) years. The actual amount available will not be determined until enactment of the FY 2027 federal budget.OPA"s Title X Family Planning Program funds "voluntary family planning projects [that] offer a broad range of acceptable and effective family planning methods and services (including natural family planning methods, infertility services, and services for adolescents)." (Title X of the Public Health Service Act, 42 U.S.C. 300 et seq., available at https://opa.hhs.gov/sites/default/files/2020-07/title-x-statute-attachment-a_0.pdf). The Title X Program is implemented through competitively awarded grants to a diverse network of public and private nonprofit entities. The program helps millions of low-income and uninsured Americans develop health literacy and access family planning and related health services, empowering individuals and families to make informed decisions and navigate chronic health conditions and pregnancy with confidence. By offering counseling and education to improve individuals" optimal health outcomes, Title X promotes the level of health literacy necessary to support informed consent across the reproductive lifespan. For example, endometriosis often goes undiagnosed for years because symptoms such as severe menstrual pain or irregular bleeding are frequently normalized or minimized. Body literacy counseling helps patients recognize that these experiences are not "normal" features of womanhood, but potential indicators of an underlying condition, prompting earlier discussion with providers, timely diagnosis, appropriate treatment, and improved long-term reproductive and overall health outcomes.Likewise, foundational knowledge of reproductive physiology enables patients and couples to recognize early signs of dysfunction, seek timely evaluation, and participate meaningfully in care decisions. Persistent gaps in reproductive knowledge highlight the need for such education. For example, a survey conducted for OPA in 2020 found that only 50% of women and 38% of men know that a woman"s ovaries do not keep producing new eggs until menopause (https://opa.hhs.gov/sites/default/files/2021-01/fertility-knowledge-survey-findings-exec-summary-2020.pdf). By supporting body literacy education alongside evidence-based evaluation and treatment of chronic disease, Title X services can help patients move beyond symptom-focused care toward informed, preventive, and restorative approaches to reproductive health.These efforts align with HHS"s focus on addressing the root causes of chronic illnesses by targeting conditions that affect reproductive health and fertility. By promoting strategies that support education and counseling on reproductive health goals, reduce chronic disease, and assist individuals seeking to achieve healthy pregnancies, the Title X Program strengthens American families, individuals, and communities.This notice solicits applications from public and private nonprofit entities to establish and operate voluntary Title X projects. These projects include a broad range of effective and acceptable services, including pregnancy testing and counseling, basic infertility services, sexually transmitted infection (STI) services (such as HIV prevention education, counseling, testing, and referral), health literacy, reproductive goals counseling to increase optimal health outcomes, and other preconception health services. Title X services also help address and provide referrals for health conditions that affect fertility, including endometriosis, polycystic ovary syndrome (PCOS), and uterine fibroids in women, as well as low sperm count, low sperm motility, low testosterone, and erectile dysfunction in men. OPA seeks a broad competition for Title X grant awards and are interested in innovative strategies to address chronic disease; reduce overmedicalization by strengthening approaches focused on underlying behavioral and lifestyle factors of health and evidence-based practices such as fertility-awareness based methods; promote health and body literacy; advance reproductive goals counseling for all clients; and support family formation.All activities funded under this announcement must be in compliance with the requirements of the Title X statute, legislative mandates, and regulations. Copies of the Title X statute, regulations, and legislative mandates may be downloaded from the OPA website at https://opa.hhs.gov/grant-programs/title- x-service-grants/title-x-statutes-regulations-and-legislative-mandates.

U.S. National Science Foundation · $5K–$47.5M

Oceanographic facilities and equipment are supported by the Integrative Programs Section (IPS) of the Division of Ocean Sciences (OCE), Directorate for Geosciences (GEO). These awards are made for the procurement, conversion and/or upgrade, enhancement, or annual operation of platforms in the ocean, coastal and near-shore waters, and Great Lakes. Awards are generally directed specifically to support facilities that lend themselves to shared use within the broad range of Federally supported research and education programs.Most of these platforms and facilities also receive partial support from other federal agencies, state and local governments, and private sources on a proportional basis usually through a daily rate mechanism. The primary objective of these awards is to ensure the availability of appropriate oceanographic facilities for Federally funded investigators and educators. Individual project-based facilities and instrumentation, limited to one, or a small group of, investigator(s), should be supported through appropriate research programs as opposed to through the IPS programs listed herein. The individual programs covered within this solicitation include: 1. Oceanographic Technical Services (Tech Services) 2. Oceanographic Instrumentation (OI) 3. Shipboard Scientific Support Equipment (SSSE) Oceanographic Technical Service (Tech Services): The Tech Services Program provides support of institutional technical services to enhance the scientific productivity of research programs, aboard research vessels and in shore-based, shared-use facilities. Research vessel technical services include quality assurance, scheduling of technical support, logistical assistance, and at-sea supervision of the instrumentation and shared-use equipment available to sea-going researchers. This program also provides baseline operational support for the University-National Oceanographic Laboratory System (UNOLS) equipment pools (wire, vans and winches). Support of research vessel technical services and UNOLS equipment pools includes salaries and related expenses, maintenance and calibration of sensors and instrumentation, and associated travel. Oceanographic technical services support requests must be directly attributable to NSF-sponsored science. With the exception of the wire pool, requests for new or replacement capital equipment must be made through the SSSE or OI programs. Oceanographic Instrumentation (OI): The OI Program provides support to enhance the scientific capabilities and productivity of seagoing research projects that utilize research vessels as well as shore-based, shared-use facilities. Proposals may include shared-use instrumentation for the collection, processing, and analysis of oceanographic data. Typical instrumentation includes sensors, acoustic systems, data loggers, water sampling rosettes, biological net systems, coring equipment and auto-analyzers. Proposals must be for instrumentation that will support multiple research projects.OI proposals are generally submitted by the institution's Tech Services manager whose operational funding is provided through the OCE Technical Services Program. Shipboard Scientific Support Equipment (SSSE): The SSSE Program provides support to improve safety and enhance scientific capabilities and productivity of seagoing research programs that utilize research vessels as well as shore-based, shared-use facilities.. Proposals may include new permanent or portable equipment required to outfit a vessel to conduct oceanographic research as well as overhaul of equipment previously funded under this program, including science handling systems (winches, frames, cranes, etc.), navigation and communication equipment, and safety and regulatory-related items. Requests for purchase of new winch pool or van pool capital equipment must be submitted to this program. SSSE proposals are generally submitted by the institution's Marine Superintendent whose operational funding is provided through the Ship Operations Program in OCE.

National Institutes of Health · Amount varies

As part of the Gabriella Miller Kids First Pediatric Research Program (Kids First Program), the NIH invites applications to submit samples from pediatric cohorts for whole genome sequencing at a Kids First Program supported genomic data generating centers. Applicants are encouraged to propose sequencing of existing pediatric cancer or congenital anomaly cohorts to elucidate the genetic contribution (somatic and/or germline) to childhood cancers, to investigate the genetic etiology of congenital anomalies, to study the molecular basis of the associations between congenital anomalies and increased cancer risk, or to expand the range of pediatric disorders included within the Kids First Data Resource. The program will accept applications that propose whole genome, exome, and transcriptome sequencing, as well as clinical-grade sequencing, long-read sequencing, proteomics, and epigenomic assays of tumor or affected tissue, when justified. Applicants are encouraged to propose cohorts to increase representation of existing Kids First Program projects. These data, and associated clinical and phenotypic data, will become part of the Kids First Data Resource Center for sharing with the research community.

National Institutes of Health · Up to $350K

This funding opportunity is part of a suite of NOFOs within the NIH HEAL Initiative to support the development of safe, effective, and non-addictive therapeutics to treat pain. The goal is to encourage initial translational efforts that will support a drug discovery program and advance projects to the point where they meet the entry criteria for the Pain Therapeutics Development Program. The scope will therefore be focused on development of assays to support a distinct testing funnel, screening efforts to identify hits, and initial characterization of hits and potential therapeutic agents (including small molecules, biologics, and natural products).

U.S. National Science Foundation · Amount varies

Through this solicitation, the Antarctic Sciences Section (ANT) of the Office of Polar Programs (OPP) funds cutting-edge research that: Improves understanding of interactions among the Antarctic region and global systems. Improves understanding of the dynamic linkages among processes operating in the Antarctic and Southern Ocean and linkages to global Earth systems, which helps inform decision making regarding environmental change. Advances fundamental understanding of Earth systems and the biological, geochemical, and physical processes in the Antarctic and Southern Ocean as drivers and responders to changes on a global scale. Expands fundamental knowledge of Antarctic systems, biota, and processes. Utilizes the unique characteristics of the Antarctic region as a science observing platform. Builds capacity and enhances the US workforce for polar-related science. ANT encourages and supports research that combines disciplinary perspectives and approaches from other fields, research that uses existing data and samples, and other research not requiring a physical presence in Antarctica.This may include projects conducted at locations outside Antarctica that serve as analogues of Antarctic sites or systems. This solicitation does not support projects that would need logistical support from the U.S. Antarctic Program (USAP).Proposers requiring USAP logistical support should consult the Antarctic Sciences web page for current opportunities. Proposers of projects with logistics needs that would be wholly provided by another Antarctic program or organization should contact an ANT Program Officer for guidance.

U.S. National Science Foundation · Up to $1.2M

The objective of the Cybersecurity Innovation for Cyberinfrastructure (CICI) program is to advance scientific discovery and innovation by enhancing the security and privacy of cyberinfrastructure. CICI supports efforts to develop, deploy and integrate cybersecurity that will benefit the broader scientific community by securing science data, computation, collaborations workflows, and infrastructure. CICI recognizes the unique nature of modern, complex, data-driven, distributed, rapid, and collaborative science and the breadth of infrastructure and requirements across scientific disciplines, practitioners, researchers, and projects. CICI seeks proposals in four program areas: 1. Usable and Collaborative Security for Science (UCSS): Projects in this program area should support novel and/or applied security and usability research that facilitates scientific collaboration, encourages the adoption of security into the scientific workflow, and helps create a holistic, integrated security environment that spans the entire scientific cyberinfrastructure ecosystem. 2. Reference Scientific Security Datasets (RSSD): Projects in this program area should leverage instrumented cyberinfrastructure to capture metadata from scientific workflows and workloads as reference data artifacts that can help support reproducible security research, testing and evaluation. 3. Transition to Cyberinfrastructure Resilience (TCR): Projects in this program area should improve the robustness, trustworthiness, integrity, and/or resilience of scientific cyberinfrastructure through testing, evaluation, hardening, validation, and technology transition of novel cybersecurity research. The TCR area further encourages transition activities that advance the deployment and use of reproducibility in CI, workflows, and data. 4. Integrity, Provenance, and Authenticity for Artificial Intelligence Ready Data (IPAAI): Projects in this program area should enhance confidence and reproducibility in AI produced scientific results by improving the integrity, provenance, and authenticity of scientific datasets used by Artificial Intelligence systems.

U.S. National Science Foundation · Up to $1M

This program seeks to prepare, nurture, and grow the national scientific research workforce for creating, utilizing, and supporting advanced cyberinfrastructure (CI) to enable and potentially transform fundamental science and engineering (S&E) research and education and contribute to the Nation's overall economic competitiveness and security. The goals of this solicitation are to (i) ensure broad adoption of CI tools, methods, and resources by the research community in order to catalyze major research advances and to enhance researchers’ abilities to lead the development of new CI, and (ii) integrate core literacy and discipline-appropriate advanced skills in advanced CI as well as computational and data-driven methods for advancing fundamental research, into the Nation’s undergraduate and graduate educational curriculum/instructional materials. Proposals responding to this solicitation may target one or both solicitation goals. For the purpose of this solicitation, advanced CI is broadly defined as the set of resources, tools, methods, and services for advanced computation, large-scale data handling and analytics, and networking and security for large-scale systems that collectively enable potentially transformative fundamental S&E research and education. This solicitation calls for innovative, scalable training, education, and curriculum/instructional materials—targeting one or more of the solicitation goals—to address emerging needs and unresolved bottlenecks in the S&E research workforce development, from the postsecondary level to active researchers to CI professionals. The funded activities, spanning targeted, multidisciplinary communities, should lead to transformative changes in the state of research workforce preparedness for advanced CI-enabled research in the short- and long-term. This solicitation also seeks to broaden CI access and adoption by (i) increasing the adoption of advanced CI and computational and data-driven methods to a broader range of S&E disciplines and institutions and (ii) effectively utilizing individual capabilities. Proposals from, and in partnership with, the aforementioned communities are especially encouraged. There are two project classes as defined below: Pilot Projects: up to $300,000 total budget with durations up to two years; and Implementation Projects: Small (with total budgets of up to $500,000) or Medium (with total budgets of up to $1,000,000) for durations of up to four years. Section II. Program Description provides a more complete description of the project classes. Section V.A. Proposal Preparation Instructions describes the proposal elements required for the various project classes in order to address the suitable set of solicitation-specific review criteria. The CyberTraining program is led by the Office of Advanced Cyberinfrastructure (OAC) in the Directorate for Computer and Information Science and Engineering (CISE) and has participation from other NSF directorates/divisions, as described in Section II. Program Description, Programmatic Areas of Interest. Not all directorates/divisions are participating at the same level, and some have specific research and education priorities. The appropriate contact for the CyberTraining program in any directorate/division is the Cognizant Program Officer (PO) for the respective directorate/division/office/program listed below. All projects are expected to clearly articulate how they will address important community needs and provide resources that will be widely available to and usable by the research community.Prospective principal investigators (PIs) are strongly encouraged to contact the Cognizant Program Officers in CISE/OAC and in the participating directorate/division relevant to the proposal to ascertain whether the focus and budget of their proposed activities are appropriate for this solicitation. Such consultations should be completed at least one month in advance of the submission deadline. PIs should include the names of the Cognizant Program Officers consulted in a Single Copy Document as described in Section V.A. Proposal Preparation Instructions. The intent of the CyberTraining program is to encourage collaboration between CI and S&E domain disciplines. (For this purpose, units of CISE other than OAC are considered domain disciplines.) To ensure relevance to community needs and to facilitate adoption, those proposals of interest to one or more domain divisions must include at least one PI/co-PI with expertise relevant to the targeted research discipline. All proposals shall include at least one PI/co-PI with expertise relevant to OAC. Prospective PIs contemplating submissions that primarily target communities relevant to directorates/divisions that are not participating in this solicitation are directed to instead explore the education and workforce development programs of the respective directorates/divisions.

National Institutes of Health · Amount varies

The purpose of the Tribal Undergraduate to Graduate Research Training and Leadership Experiences (TURTLE) program is to fund federally recognized American Indian/Alaska Native (AI/AN) Tribes, tribal colleges or universities, Tribal health programs, or Tribal organizations (collectively termed, eligible Tribal Entities) to identify and develop a pool of scientists to conduct research on AI/AN health and health disparities. Through this Notice of Funding Opportunity (NOFO), NIGMS will provide support for a phased award to eligible AI/AN Tribal Entities to develop (UE5) and implement (T32) effective training and mentoring activities for research-oriented individuals earning a doctoral degree in a biomedical research field at a variety of institutions across the United States and territories. The overall purpose is to support the development of individuals who have the technical, operational, and professional skills required to conduct AI/AN health research in a culturally appropriate, ethically responsible and rigorous manner, to complete Ph.D.s in a biomedical field, and to transition into careers in the biomedical research workforce.