Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH UG3/UH3 funds discovery and development of interventions — medication…
- Deadline
- Aug 21, 2028
- Posted
- Sep 10, 2025
- Award amount
- Up to $3,000,000
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We’ll email you before Aug 21, 2028 so you have time to apply.
In plain English
Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH UG3/UH3 funds discovery and development of interventions — medications and devices — to prevent and treat substance use disorders and overdose, including preclinical and clinical studies. Awards up to about $3,000,000.
AI-generated summary to help you decide quickly — verify the official eligibility rules before applying.
Who can apply
Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.
About this grant
The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.
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