Health Grants for Governments & tribes

National Institutes of Health · Amount varies

Open to U.S. universities, research institutions, nonprofits, foreign organizations, and certain government/tribal entities. This NIH X01 provides access to TOPMed genomic and multi-omics data resources to study heart, lung, blood, and sleep disorders — it offers data generation, not direct funding. Aimed at researchers doing functional-genomics and mechanism studies.

National Institutes of Health · Up to $2.1M

Open to U.S. research institutions and universities, nonprofits, and certain government/tribal organizations; foreign organizations cannot apply, and (as of May 2025) projects with foreign subawards are ineligible. This NIH U2C-TL1 funds institutional networks that recruit and train researchers in kidney, urologic, and hematologic disease research. Awards up to about $2,100,000.

National Institutes of Health · Amount varies

Open to eligible NIGMS-funded investigators and new investigators at U.S. institutions; foreign organizations are not eligible, and projects with foreign subawards are excluded. This NIH R35 (MIRA) gives an investigator stable, flexible single-grant support for their lab's research within the NIGMS mission, rather than project-by-project funding. Early-stage investigators should use the separate ESI MIRA notice.

National Institutes of Health · Amount varies

Open to U.S. universities, research institutions, nonprofits, and certain government/tribal organizations; foreign organizations are not eligible. This NIH R61/R33 funds mechanistic clinical research on how mind-and-body interventions (e.g., meditation, yoga, acupuncture) affect emotional well-being and whole-person health, in two milestone-tied phases. Strong preliminary data are expected.

National Institutes of Health · Up to $500K

Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH R01 funds groundbreaking, high-impact Down syndrome research across any relevant topic, with no preliminary data required. Awards up to about $500,000.

National Institutes of Health · Up to $200K

Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH R21 funds exploratory, higher-risk Down syndrome research — feasibility studies, novel methods, or new applications of existing techniques. Awards up to about $200,000.

National Institutes of Health · Amount varies

Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH R61/R33 funds milestone-driven development of clinical trials to treat co-occurring health conditions in people with Down syndrome — up to two years of planning followed by up to three years of trial support. Clinical trials are required.

National Institutes of Health · Amount varies

Open specifically to federally recognized American Indian/Alaska Native tribes, tribal colleges and universities, tribal health programs, and tribal organizations. This NIH R34 planning grant funds preparatory work to develop competitive Native American Research Centers for Health (NARCH) applications. Eligibility is narrow — limited to AI/AN tribal entities; award size follows standard R34 limits.

National Institutes of Health · Amount varies

Open to U.S. universities, research institutions, nonprofits, and certain government/tribal organizations; foreign organizations are not eligible. This NIH R21 funds projects that improve clinical-trial readiness for rare diseases — developing biomarkers and outcome measures, or characterizing a disease's course to enable future trials. Award size follows standard R21 limits.

National Institutes of Health · Up to $3M

Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH UG3/UH3 funds discovery and development of interventions — medications and devices — to prevent and treat substance use disorders and overdose, including preclinical and clinical studies. Awards up to about $3,000,000.

National Institutes of Health · Up to $500K

Open to U.S. universities, research institutions, nonprofits, and certain government/tribal organizations; foreign organizations are not eligible. This NIH R01 funds development of non-invasive or minimally invasive technologies to image the human olfactory system at high resolution. Awards up to about $500,000; multidisciplinary teams are encouraged.

National Institutes of Health · Amount varies

Open to U.S. universities, research institutions, nonprofits, and certain government/tribal organizations; foreign organizations are not eligible. This NIH R01 supports early-stage investigators pursuing a new research direction, and applications must include no preliminary data. Award size follows standard R01 limits; aimed at researchers early in their independent careers.

National Institutes of Health · Amount varies

Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH/NCI R21 funds early-stage, exploratory research on cancer control — prevention behaviors, screening, etiology, and novel methods. Award size follows standard R21 limits.

National Institutes of Health · Amount varies

Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH DP1 (Avant-Garde/Avenir) funds high-risk, high-reward research on HIV and substance use — basic, clinical, translational, or implementation science. It backs bold, transformative ideas; award size follows the DP1 mechanism.

National Institutes of Health · Up to $400K

This NIH R01 grant funds research into early immune system development from the prenatal period through early childhood, including effects of in-utero HIV or antiretroviral exposure. A broad range of applicants is eligible, including colleges and universities, tribal governments, faith- and community-based organizations, minority-serving institutions, and foreign organizations. The award ceiling is up to about $400,000.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-IP-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. The entry is a placeholder for Type 6 (continuation/competing renewal) applications and does not state award amounts or program specifics. Because it appears aimed at existing grantees, check with CDC about eligibility if you have not held a prior award.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-OE-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. It is listed only as a placeholder for Type 6 (continuation/competing renewal) applications, with no award amounts or detailed requirements. Since it appears intended for existing grantees, confirm eligibility with CDC before applying as a new applicant.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-DD-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. It is a placeholder listing for renewal-type applications and provides no award amounts or detailed program requirements. As it appears geared toward existing grantees, confirm eligibility with CDC before applying as a new applicant.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-DP-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. The entry is a placeholder for Type 6 (continuation/competing renewal) applications and does not list award amounts or program details. As it appears geared toward existing grantees, check with CDC about eligibility before applying as a new organization.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-EH-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. It is a placeholder for Type 6 (continuation/competing renewal) applications, with no stated award amounts or detailed requirements. Because it appears aimed at existing grantees, confirm eligibility with CDC if you are a first-time applicant.