Grants for State, Local & Tribal Governments

Department of Housing and Urban Development · $112.5K–$250K

A HUD program providing one-time, cost-reimbursable grants for service coordination and limited direct services to residents of HUD-assisted housing facing emergencies such as natural disasters or public-health crises. Eligible applicants include public/Indian housing authorities, nonprofits (with or without 501(c)(3) status, including resident associations), multifamily owners, Tribal governments and entities, and faith-based organizations, so eligibility is relatively broad among housing-connected organizations. Awards run roughly $112,500 to $250,000. Note that funds are reimbursed after costs are incurred and serve HUD-assisted housing residents specifically.

National Institutes of Health · Amount varies

An NIH UE5/T32 award that funds federally recognized American Indian/Alaska Native Tribes, Tribal colleges, Tribal health programs, and Tribal organizations to build graduate-level research training in AI/AN health. Eligibility is restricted to qualifying Tribal entities; foreign organizations are not eligible. No award amount is specified. This is a narrow opportunity limited to Tribal applicants and is not a fit for other nonprofits, small businesses, or individuals.

National Institutes of Health · Amount varies

An NIH UE5/T34 award funding federally recognized American Indian/Alaska Native Tribes, Tribal colleges, Tribal health programs, and Tribal organizations to develop undergraduate-level research training in AI/AN health. Eligibility is restricted to qualifying Tribal entities; foreign organizations are not eligible. No award amount is specified. Like its T32 counterpart, this is narrow and not a fit for non-Tribal nonprofits, small businesses, or individuals.

U.S. National Science Foundation · $1M–$1.5M

An NSF EPSCoR program funding interjurisdictional research collaborations in STEM, open to higher-education institutions, certain nonprofit research organizations with 501(c)(3) status, and Tribal governments located in EPSCoR-eligible jurisdictions. Applicants and investigators must be in EPSCoR jurisdictions and projects must span at least two such jurisdictions, which is a significant geographic restriction. Awards run roughly $1,000,000 to $1,500,000. Not a fit for organizations outside EPSCoR-eligible jurisdictions or without a research mission.

National Institutes of Health · Amount varies

An NIH R24 funding federally recognized American Indian/Alaska Native Tribes, Tribal colleges, Tribal health programs, and Tribal organizations to establish or strengthen Tribal Institutional Review Boards. Eligibility is restricted to qualifying Tribal entities; foreign organizations are not eligible, and clinical trials are not allowed. No award amount is specified. This is narrow and not a fit for non-Tribal nonprofits, small businesses, or individuals.

Centers for Disease Control - OPHPR · $50K–$5M

A CDC cooperative agreement that pre-positions states, large local governments, and federally recognized Tribes on an approved-but-unfunded roster for rapid public-health emergency response. Eligibility is limited to government public-health entities, with population thresholds (e.g., counties of 2 million or more, cities of 400,000 or more, Tribes serving 50,000 or more), so it is restricted to large jurisdictions. Listed award range is about $50,000 to $5,000,000, but funding is only released if a public health emergency is declared. Not a fit for nonprofits, small businesses, individuals, or smaller jurisdictions.

U.S. National Science Foundation · $100K–$750K

An NSF program funding research on the coupling, energetics, and dynamics of the upper atmosphere, including ground- and space-based observations and modeling. Eligibility is relatively broad: U.S. for-profit organizations including small businesses, nonprofit non-academic research organizations, higher-education institutions, and federally recognized Tribal Nations may apply. Awards run roughly $100,000 to $750,000. While the entity types are broad, the work is specialized atmospheric science suited to research-capable applicants.

U.S. National Science Foundation · $300K–$1M

An NSF program funding development and testing of innovative approaches to STEM graduate education. Eligible applicants are U.S. two- and four-year higher-education institutions (including community colleges), certain nonprofit non-academic research/education organizations, and federally recognized Tribal Nations. Awards run roughly $300,000 to $1,000,000. This is geared to colleges, universities, and education-focused nonprofits rather than small businesses or individuals.

Dept of the Army -- Materiel Command · Amount varies

A U.S. Army (West Point / U.S. Military Academy) Broad Agency Announcement soliciting basic and applied research and analysis across science, engineering, education, policy, ethics, history, and economics. Eligibility is broad, including higher-education institutions, nonprofits, state and local governments, for-profit organizations (large and small businesses), and foreign organizations/public entities, with no restriction on place of performance. No award amount is specified, and funding depends on the specific proposal. Proposals must advance the state of the art or basic knowledge rather than target specific devices.

Food and Drug Administration · $0–$300K

Strictly limited to state animal food safety programs that hold an FDA inspectional contract in good standing and a valid 20.88 agreement with FDA; other applicants are not eligible. This FDA cooperative agreement funds implementation and maintenance of the Animal Food Regulatory Program Standards and optional mutual-reliance projects to integrate federal and state food-safety work. Development-track applicants may request up to about $300,000 per year, and ongoing FDA inspection/audit obligations apply.

National Institutes of Health · Up to $200K

Open to U.S. research and education organizations including universities, minority-serving institutions, tribal governments, and faith- and community-based groups under this NIH R25 research-education mechanism; foreign organizations and foreign components are not eligible to apply. Funds short courses for skills development that teach innovative methods and approaches in the behavioral and social sciences. No clinical trial is allowed; awards are capped at about $200,000 per year.

U.S. National Science Foundation · Amount varies

This NSF program funds open-science work such as research data management, cyberinfrastructure, and scientific publication models that make research data findable, accessible, interoperable, and reusable. Eligibility is limited to U.S. institutions of higher education, non-profit non-academic research organizations, federally recognized tribal nations, and certain federal agencies and FFRDCs. No award amount is listed.

National Institutes of Health · Amount varies

Open to U.S. research organizations including universities, minority-serving institutions, tribal governments, and faith- and community-based groups under this NIH R01; the listing states foreign organizations and foreign components/organizations are not eligible to apply. Funds research testing innovative ways to implement screening, brief intervention, and referral to treatment or prevention (SBIRT/P) for alcohol, tobacco, and other drug use in adult populations experiencing health disparities. A clinical trial is required and applicants should partner with healthcare and community organizations; no specific award amount is listed.

National Institutes of Health · Amount varies

Open to U.S. research organizations including universities, minority-serving institutions, tribal governments, and faith- and community-based groups under this NIH R01 (clinical trial optional); the listing states foreign organizations and foreign components/organizations are not eligible to apply despite being mentioned. Funds research on family health, well-being, and resilience to advance minority health and reduce health disparities. No specific award amount is stated.

U.S. National Science Foundation · Amount varies

This NSF solicitation funds Antarctic research that requires logistical fieldwork support from the U.S. Antarctic Program (USAP), spanning Earth systems, biological, geochemical, and physical sciences. Eligible applicants are limited to U.S.-based non-profit non-academic research organizations (such as museums, observatories, and research laboratories), accredited U.S. institutions of higher education, and federally recognized tribal nations; individuals and businesses are not among the listed eligible submitters. Available USAP logistical support is currently limited due to facility maintenance, so applicants should follow the solicitation's guidance. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH (R33) opportunity funds mechanistic research to advance precision probiotic therapies by characterizing person-specific factors that affect probiotic responses, using animal models or human subjects. Eligible applicants are U.S. research organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. It expects supportive preliminary data and is intended for established research teams, not individuals or general nonprofits. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH (R61/R33) phased opportunity funds mechanistic research to advance precision probiotic therapies, beginning with an exploratory phase to identify person-specific factors and a second phase to test them in animal models or human subjects, over a combined period of up to five years. Eligible applicants are U.S. research organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. Transition between phases depends on meeting milestones. It is intended for established research teams, not individuals or general nonprofits. Award amounts are not specified.

Department of Housing and Urban Development · $0

This HUD notice of intent previews a future opportunity inviting unsolicited research proposals on housing and community development priorities such as affordability, homelessness, and housing stability. Eligible applicants are philanthropic entities (including 501(c)(3) foundations and public charities), other federal agencies, state or local governments, Indian tribes, tribally-designated housing entities, and colleges or universities; individuals, foreign entities, and sole proprietorships are not eligible, and no profit may be earned. Note a significant disqualifier: projects must include matching funds equal to at least 50 percent of total project cost. Award amounts are not specified in the notice.

National Institutes of Health · Amount varies

Open to domestic research organizations including universities, minority-serving institutions, tribal governments, and faith- and community-based groups under this NIGMS R24 resource award; foreign organizations and foreign components are not eligible. Funds shared resources that give a regional (multi-state) or national user base access to state-of-the-art equipment, technologies, tools, materials, software, or services within NIGMS program areas, including web presence, outreach, and user training. Resources should already exist or be formed from existing facilities; no specific award amount is stated.

National Institutes of Health · Amount varies

This NIH BRAIN Initiative (U01) program funds development of next-generation sensors and bioelectronic devices that synchronize with brain recordings to build computational models of human and animal behavior. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it targets established research and technology-development teams, not individuals or general nonprofits. Award amounts are not specified. Confirm program-specific eligibility in the full announcement.