Grants for State, Local & Tribal Governments

Centers for Disease Control - OPHPR · $50K–$5M

A CDC cooperative agreement that pre-positions states, large local governments, and federally recognized Tribes on an approved-but-unfunded roster for rapid public-health emergency response. Eligibility is limited to government public-health entities, with population thresholds (e.g., counties of 2 million or more, cities of 400,000 or more, Tribes serving 50,000 or more), so it is restricted to large jurisdictions. Listed award range is about $50,000 to $5,000,000, but funding is only released if a public health emergency is declared. Not a fit for nonprofits, small businesses, individuals, or smaller jurisdictions.

U.S. National Science Foundation · $100K–$750K

An NSF program funding research on the coupling, energetics, and dynamics of the upper atmosphere, including ground- and space-based observations and modeling. Eligibility is relatively broad: U.S. for-profit organizations including small businesses, nonprofit non-academic research organizations, higher-education institutions, and federally recognized Tribal Nations may apply. Awards run roughly $100,000 to $750,000. While the entity types are broad, the work is specialized atmospheric science suited to research-capable applicants.

U.S. National Science Foundation · $300K–$1M

An NSF program funding development and testing of innovative approaches to STEM graduate education. Eligible applicants are U.S. two- and four-year higher-education institutions (including community colleges), certain nonprofit non-academic research/education organizations, and federally recognized Tribal Nations. Awards run roughly $300,000 to $1,000,000. This is geared to colleges, universities, and education-focused nonprofits rather than small businesses or individuals.

Dept of the Army -- Materiel Command · Amount varies

A U.S. Army (West Point / U.S. Military Academy) Broad Agency Announcement soliciting basic and applied research and analysis across science, engineering, education, policy, ethics, history, and economics. Eligibility is broad, including higher-education institutions, nonprofits, state and local governments, for-profit organizations (large and small businesses), and foreign organizations/public entities, with no restriction on place of performance. No award amount is specified, and funding depends on the specific proposal. Proposals must advance the state of the art or basic knowledge rather than target specific devices.

U.S. National Science Foundation · Amount varies

This NSF program funds open-science work such as research data management, cyberinfrastructure, and scientific publication models that make research data findable, accessible, interoperable, and reusable. Eligibility is limited to U.S. institutions of higher education, non-profit non-academic research organizations, federally recognized tribal nations, and certain federal agencies and FFRDCs. No award amount is listed.

U.S. National Science Foundation · Amount varies

This NSF solicitation funds Antarctic research that requires logistical fieldwork support from the U.S. Antarctic Program (USAP), spanning Earth systems, biological, geochemical, and physical sciences. Eligible applicants are limited to U.S.-based non-profit non-academic research organizations (such as museums, observatories, and research laboratories), accredited U.S. institutions of higher education, and federally recognized tribal nations; individuals and businesses are not among the listed eligible submitters. Available USAP logistical support is currently limited due to facility maintenance, so applicants should follow the solicitation's guidance. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH (R33) opportunity funds mechanistic research to advance precision probiotic therapies by characterizing person-specific factors that affect probiotic responses, using animal models or human subjects. Eligible applicants are U.S. research organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. It expects supportive preliminary data and is intended for established research teams, not individuals or general nonprofits. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH (R61/R33) phased opportunity funds mechanistic research to advance precision probiotic therapies, beginning with an exploratory phase to identify person-specific factors and a second phase to test them in animal models or human subjects, over a combined period of up to five years. Eligible applicants are U.S. research organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. Transition between phases depends on meeting milestones. It is intended for established research teams, not individuals or general nonprofits. Award amounts are not specified.

Department of Housing and Urban Development · $0

This HUD notice of intent previews a future opportunity inviting unsolicited research proposals on housing and community development priorities such as affordability, homelessness, and housing stability. Eligible applicants are philanthropic entities (including 501(c)(3) foundations and public charities), other federal agencies, state or local governments, Indian tribes, tribally-designated housing entities, and colleges or universities; individuals, foreign entities, and sole proprietorships are not eligible, and no profit may be earned. Note a significant disqualifier: projects must include matching funds equal to at least 50 percent of total project cost. Award amounts are not specified in the notice.

National Institutes of Health · Amount varies

This NIH BRAIN Initiative (U01) program funds development of next-generation sensors and bioelectronic devices that synchronize with brain recordings to build computational models of human and animal behavior. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it targets established research and technology-development teams, not individuals or general nonprofits. Award amounts are not specified. Confirm program-specific eligibility in the full announcement.

National Institutes of Health · Amount varies

This NIH (NIDCD, R21) opportunity is a planned re-issue to support early-stage dissemination and implementation research in hearing, balance, taste, smell, voice, speech, and language. For this announcement foreign organizations and non-U.S. components are eligible to apply, but NIH will not issue awards involving foreign subawards/subcontracts unless submitted under a specifically designated international-collaboration announcement. Note the announcement states applications are not being solicited at this time, so it is a notice of intent rather than an open call. It is intended for research institutions, not individuals or general nonprofits. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH (R21) opportunity funds preclinical efficacy studies in established rare-disease models to demonstrate that a candidate therapeutic warrants further development, including supporting pharmacokinetic and pharmacodynamic studies. Eligible applicants are U.S. research organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. It is intended for research teams advancing therapeutic candidates, not individuals or general nonprofits. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH mechanism is narrowly limited to organizations that already hold specific types of NIH grants and need to transfer an existing award to a new recipient institution (a change of recipient organization). It is an administrative prior-approval request, not a new funding opportunity, and there is no guarantee a transfer will be approved. Only current NIH grantee organizations should apply; it does not apply to individuals, new applicants, or general nonprofits. No award amount applies.

National Institutes of Health · Amount varies

This NIH mechanism is narrowly limited to organizations that already hold specific NIH grants and need to transfer an award due to a change in organizational status (successor-in-interest). It is an administrative prior-approval request, not a new funding opportunity, and approval of the transfer is not guaranteed. Only current NIH grantee organizations should use it; it does not apply to individuals, new applicants, or general nonprofits. No award amount applies.

National Institutes of Health · Amount varies

This NIH program supports preclinical discovery and development of biologic-based therapies for nervous system disorders, from lead optimization through Phase I clinical testing. Eligible applicants are research organizations such as universities, colleges, government and tribal agencies, faith- or community-based organizations, and (for this announcement) foreign organizations; it is geared toward established research teams, not individuals or general nonprofits. Award amounts are not specified. Applicants should be prepared for a complex, multi-phase research undertaking with NIH-funded consultants and contract research organizations.

Bureau of Reclamation · $1K–$40M

This Bureau of Reclamation Title XVI program funds planning, design, and construction of water reclamation and reuse projects, with awards reported up to about $40 million. Eligible applicants are state, regional, or local authorities such as states, tribes, municipalities, irrigation, water, and wastewater districts, and other water/power delivery organizations located in named Western states or territories; eligibility is further limited to sponsors of specific authorized Title XVI projects or projects qualifying under the WIIN Act. Federal entities, foreign entities, individuals, and institutions of higher education are not eligible. WaterSMART projects typically require a substantial non-federal cost share, so confirm terms in the full announcement; this is a large-award, narrowly restricted program for public water agencies.

Bureau of Reclamation · $1K–$120M

This Bureau of Reclamation program funds planning, design, and construction of seawater or brackish-water desalination facilities, with awards reported up to about $120 million. Eligible applicants are states and their subdivisions and public agencies such as tribes, municipalities, irrigation, water, and wastewater districts, and all applicants must be located in one of 17 named Western states. Federal entities, foreign entities, individuals, and institutions of higher education are not eligible. WaterSMART construction projects typically require a substantial non-federal cost share, so confirm the cost-share terms in the full announcement; this is a large-award, geographically restricted program for public water agencies.

National Institutes of Health · Amount varies

This NIH (R13) program supports conferences and scientific meetings relevant to public health and the missions of participating NIH institutes. Eligible applicants are U.S. research and education organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply, though some foreign components are allowed. Note that R13 conference support typically requires advance permission from the funding institute before applying. It is aimed at organizations hosting scientific conferences, not individuals. Award amounts are not specified.

National Institutes of Health · Amount varies

This NIH (R21) opportunity supports exploratory research in computational genomics, data science, statistics, and bioinformatics relevant to basic or clinical genomic science and human health. Eligible applicants are research organizations including universities, colleges, government and tribal entities, and faith- or community-based organizations; it is intended for established research teams rather than individuals or general nonprofits. Award amounts are not specified. Methods should be generalizable and scalable to large datasets.

National Institutes of Health · Amount varies

This NIH (R01) opportunity funds non-pharmacological interventions to promote sleep health and reduce sleep-related health disparities among populations that experience health disparities. Eligible applicants are U.S. research organizations including universities, government and tribal entities, and faith- or community-based organizations; foreign organizations and non-U.S. components are not eligible to apply. It is intended for established research teams, not individuals or general nonprofits. Award amounts are not specified.