Grants for State, Local & Tribal Governments

U.S. National Science Foundation · Amount varies

This NSF INCLUDES program funds collaborative, national-scale efforts to broaden participation and build inclusive infrastructure in STEM, supporting pilots, consortia, alliances, network connectors, and conferences. Eligibility is relatively broad: for-profit organizations including small businesses, nonprofit non-academic organizations, state and local governments, institutions of higher education, and federally recognized tribal nations may apply. No specific award amounts are listed. This is a research and capacity-building opportunity open to a range of organizations, though not to individuals.

National Institutes of Health · Amount varies

This NIH X01 opportunity provides access to biospecimens (urine, plasma, serum, genomic DNA) and related data from the Population Assessment of Tobacco and Health (PATH) Study rather than direct research funding. It is aimed at investigators at universities, research institutions, and similar eligible organizations, including various minority-serving institutions and tribal entities. Foreign (non-U.S.) organizations and foreign components are not eligible. No award amounts are listed; this is a resource-access mechanism for researchers, not a general grant for nonprofits, businesses, or individuals.

U.S. Dept. of Treasury RESTORE Act Program · $0–$120.2M

This Treasury RESTORE Act Direct Component opportunity funds construction and real property acquisition activities for Gulf Coast restoration, including environmental restoration and infrastructure projects. Only state and county governments may apply. Awards can be very large, up to roughly $120 million. Some projects may involve a non-federal cost-share for other federally funded programs, though cost-share is described as optional here. Nonprofits, businesses, individuals, and researchers are not eligible to apply directly.

Fish and Wildlife Service · $25K–$2.3M

This US Fish and Wildlife Service program is the Base Funding round of the Highlands Conservation Act, funding land conservation projects in the Highlands Region of CT, NJ, NY, and PA. Only the Governor-designated Lead State Agency in each of the four states may apply, so eligibility is narrowly restricted to those government agencies (funds may be subawarded to counties or municipalities). Each state may request up to about $2.29 million, with awards from roughly $25,000 upward, and the program funds up to 50% of project cost, requiring a non-federal match. Nonprofits, businesses, and individuals cannot apply directly.

Fish and Wildlife Service · $25K–$3.9M

This US Fish and Wildlife Service program funds land conservation projects in the Highlands Region of CT, NJ, NY, and PA, where a state, county, or municipal entity acquires land or land interests from willing sellers. Only the Lead State Agency designated by each Highlands state's Governor may apply, so eligibility is restricted to those specific government agencies (funds may be subawarded to counties or municipalities). Awards range from roughly $25,000 to $3.85 million, and the program covers up to 50% of project cost, meaning a non-federal match is required. Nonprofits, businesses, individuals, and most organizations cannot apply directly.

U.S. Dept. of Treasury RESTORE Act Program · $5.7M–$14.5M

This Treasury RESTORE Act program funds Centers of Excellence research on Gulf Coast coastal sustainability, fisheries, offshore energy, economic growth, and Gulf monitoring. Only state governments may be the direct applicant; eligible states then issue competitive subawards to nongovernmental entities and consortia, including universities. Awards range from roughly $5.7 million to $14.5 million. Because only state governments can apply directly, nonprofits, businesses, individuals, and researchers would need to participate through a state's subaward process rather than apply themselves.

U.S. Dept. of Treasury RESTORE Act Program · $0–$120.2M

This Treasury RESTORE Act Direct Component opportunity funds non-construction activities tied to Gulf Coast restoration, mitigation, workforce development, infrastructure planning, tourism, and related eligible uses. Only state and county governments may apply. Awards can be very large, up to roughly $120 million. Some projects may involve a non-federal cost-share for other federally funded programs, though cost-share is described as optional here. Nonprofits, businesses, individuals, and researchers are not eligible to apply directly.

National Institutes of Health · Amount varies

This NIH R61 grant supports exploratory clinical trials in arthritis, musculoskeletal, and skin diseases, and a clinical trial is required. It is a research grant for universities, research institutions, and similar eligible organizations, including various minority-serving institutions and tribal entities. Foreign (non-U.S.) organizations are not eligible to apply, though defined foreign components are allowed. No specific award amounts are listed, and eligibility is oriented toward research institutions rather than nonprofits, small businesses, or individuals broadly.

National Institutes of Health · Amount varies

This NIH R01 grant funds clinical observational studies in musculoskeletal, rheumatic, and skin diseases. It is a research grant for universities, research institutions, and similar eligible organizations, including various minority-serving institutions and tribal entities. Foreign (non-U.S.) organizations are not eligible to apply, though defined foreign components are allowed; clinical trials are not permitted under this opportunity. No specific award amounts are listed, and eligibility is oriented toward research institutions rather than nonprofits, small businesses, or individuals broadly.

National Institutes of Health · Amount varies

This NIH R01 grant supports development of novel theory and methods to understand how genetic and non-genetic factors shape complex human traits, using interdisciplinary modeling and large-scale datasets. It is a research grant aimed primarily at universities, research institutions, and similar eligible organizations, including various minority-serving institutions, tribal entities, and foreign organizations. No award amounts are specified. Clinical trials are not allowed under this opportunity, and the eligibility list is research-institution oriented rather than open to nonprofits, small businesses, or individuals broadly.

National Institutes of Health · Up to $350K

This NIH/NCI R01 grant funds secondary analysis and integration of existing datasets to study cancer risk and related outcomes such as survival and treatment response. It is a research grant for universities, research institutions, and similar eligible organizations, including various minority-serving institutions, tribal entities, and foreign organizations. The award maximum is about $350,000. Eligibility is oriented toward research institutions rather than nonprofits, small businesses, or individuals broadly, and applicants typically need access to relevant existing data.

U.S. National Science Foundation · Amount varies

NSF FINDERS FOUNDRY program funding partnerships of K-12 educators, technologists, and researchers to develop technology-based solutions to learning and workforce challenges, with a focus on early AI exposure. Eligible applicants are limited to US nonprofits/non-academic research organizations, state and local governments, US institutions of higher education, and federally recognized tribal nations; unaffiliated individuals cannot apply and no PI degree is required. Only teams awarded planning grants may later submit development proposals. No award amount is specified.

Fish and Wildlife Service · $5K–$150K

This Fish and Wildlife Service program funds implementation of approved state and interstate Aquatic Nuisance Species management plans. Eligibility is narrow: only states, territories, or Indian tribes (within an interstate organization) that have an approved ANS management plan may apply, with a specific named list of eligible state entities. A 25% cost-share of total project costs is required, and there is a 5% cap on administrative costs. Awards range from about $5,000 to $150,000.

Department of Homeland Security - FEMA · Amount varies

This FEMA Flood Mitigation Assistance Swift Current program funds flood mitigation for buildings insured under the National Flood Insurance Program in participating communities. Eligibility is narrow and government-only: states, U.S. territories, the District of Columbia, federally recognized tribal governments, and local governments (which must apply through their state or territory). It is not available to nonprofits, businesses, or individuals directly. No specific award amount is stated in this record.

National Institute of Food and Agriculture · $10K–$10M

The USDA AFRI Foundational and Applied Science program funds research, education, and extension projects across six agricultural priority areas. Eligibility is broad and includes universities and colleges, state agricultural experiment stations, research institutions, private organizations or corporations, federal agencies, and U.S.-citizen or permanent-resident individuals; foreign and international organizations are not eligible. Awards range widely from about $10,000 up to $10 million depending on project type. Eligibility for specific grant types varies by program area, so applicants should check the RFA.

National Institute of Food and Agriculture · $150K–$2.5M

This USDA NIFA Tribal Colleges Research Grants Program builds research capacity at the 1994 Land-Grant Tribal Colleges in agriculture, natural resources, and human sciences. Eligibility is narrow: only the named list of eligible 1994 Tribal Colleges may apply. Awards range from about $150,000 to $2.5 million. It is restricted to those specific institutions, and gain-of-function research is excluded.

National Institute of Food and Agriculture · $10K–$650K

The USDA AFRI Education and Workforce Development program funds projects that develop the next generation of food and agricultural sciences professionals, including K-14 educator development, youth education, community-college training, undergraduate research, and pre/postdoctoral fellowships. Eligibility is broad and includes colleges and universities, experiment stations, research institutions, private organizations, federal agencies, and U.S.-citizen or permanent-resident individuals; foreign and international organizations are not eligible. Awards range from about $10,000 to $650,000. Eligibility varies by project type, so applicants should check the NOFO.

Fish and Wildlife Service · $20K–$923.8K

This Fish and Wildlife Service program funds interjurisdictional aquatic invasive species projects spanning Great Lakes state and tribal management plans. Eligibility is narrow: only Great Lakes states and tribes (or their designees) may apply, with one application sought from a state and tribal natural resource agency. Awards range roughly from $20,000 to about $924,000. It is aimed at state and tribal natural resource agencies.

Fish and Wildlife Service · $100K–$600K

This Fish and Wildlife Service program funds implementation of aquatic invasive species management plans in the Great Lakes states. Eligibility is narrow: only a primary state natural resource agency in each Great Lakes state may apply, though that agency may designate another entity of any type to apply on its behalf. Awards range roughly from $100,000 to $600,000. Most applicants will need an existing state plan and a connection to a state natural resource agency to be eligible.

Fish and Wildlife Service · $20K–$100K

This Fish and Wildlife Service program funds development or implementation of tribal aquatic invasive species management plans in the Great Lakes Basin. Eligibility is narrow: only tribal natural resource agencies or organizations in the Great Lakes Basin may apply, though they may designate another entity of any type to apply on their behalf. Awards range roughly from $20,000 to $100,000. A relevant tribal AIS plan must exist or be developed as part of the work.