Grants for State, Local & Tribal Governments

Fish and Wildlife Service · $20K–$923.8K

This Fish and Wildlife Service program funds interjurisdictional aquatic invasive species projects spanning Great Lakes state and tribal management plans. Eligibility is narrow: only Great Lakes states and tribes (or their designees) may apply, with one application sought from a state and tribal natural resource agency. Awards range roughly from $20,000 to about $924,000. It is aimed at state and tribal natural resource agencies.

Environmental Protection · Amount varies

Pennsylvania's Recycling Program Performance Grant funds local government recycling programs, with award amounts based on total tons recycled and the municipality's recycling rate. Only Pennsylvania municipalities with existing recycling programs are eligible. The deadline is December 31, 2026.

National Institutes of Health · Amount varies

This NIH/NHLBI R61/R33 supports investigator-initiated Phase I clinical trials for therapeutics or diagnostics for heart, lung, blood, and sleep disorders, with the first phase funding final pre-trial preparation. A clinical trial is required. Eligible applicants include universities, research institutions, tribal and community organizations, and foreign organizations. It is aimed at research teams with clinical-trial capacity. No specific award amount is stated.

National Institutes of Health · Amount varies

This NIH R34 planning grant supports research on prevention and intervention strategies for fetal alcohol spectrum disorders across the lifespan, intended as a precursor to larger studies. Eligible applicants include universities, research institutions, and tribal and community organizations, and foreign organizations are listed among eligible applicants. It is aimed at research teams preparing for larger FASD studies. No specific award amount is stated.

National Institutes of Health · Amount varies

This NIH R21 funds development of novel theory and methods for understanding the genetic architecture of complex human traits, using interdisciplinary approaches, simulations, and existing large-scale datasets; no clinical trial is allowed. Eligible applicants include universities, research institutions, tribal and community organizations, and foreign organizations. It is aimed at research teams with methodological expertise. No specific award amount is stated.

National Institutes of Health · Up to $1.5M

This NIH/NHLBI R33 supports investigator-initiated Phase I clinical trials for therapeutics or diagnostics for heart, lung, blood, and sleep disorders; a clinical trial is required and applicants must be ready to start the trial early. Eligible applicants include universities, research institutions, and tribal and community organizations; foreign organizations are not eligible to apply, though non-U.S. components of U.S. organizations are. The maximum award is about $1.5 million. It requires clinical-trial readiness.

National Institutes of Health · Up to $250K

This NIH/National Library of Medicine R01 funds development of informatics and data science approaches that give individuals actionable insights into their own health; a clinical trial is optional. Eligible applicants include universities, research institutions, and tribal and community organizations, and foreign organizations are listed among eligible applicants. The maximum award is about $250,000. It requires informatics research capacity.

National Institutes of Health · Amount varies

This NIH/National Cancer Institute R01 supports investigator-initiated clinical trials in cancer prevention and control, such as early detection, screening, and survivorship research. Typical applicants are universities, research institutions, hospitals, tribal organizations, and government and community organizations; foreign organizations are listed among eligible applicants here. A qualifying clinical trial is required, so it is geared toward established research teams. No specific award amount is stated.

National Institutes of Health · Up to $500K

This NIH/National Cancer Institute R01 funds investigator-initiated early-phase (Phase 0, I, II) clinical trials for cancer diagnosis and treatment; a clinical trial is required. Eligible applicants include universities, research institutions, hospitals, tribal and community organizations, and foreign organizations. The maximum award is just under $500,000. It is geared toward established clinical research teams.

National Institutes of Health · Amount varies

This NIH R01 funds preclinical and patient-based research into how incretin mimetics (such as GLP-1 agents) affect cancer risk. Eligible applicants include universities, research institutions, tribal and community organizations, and foreign organizations; a clinical trial is optional. It requires established research capacity in this area. No specific award amount is stated.

National Institutes of Health · Amount varies

This NIH R21 funds preclinical and patient-based research into how incretin mimetics (such as GLP-1 agents) affect cancer risk; no clinical trial is allowed. Eligible applicants include universities, research institutions, tribal and community organizations, and foreign organizations. It requires research capacity in this area. No specific award amount is stated.

National Institutes of Health · Amount varies

This NIH R01 supports research on improving access to and quality of evidence-based practices for youth mental health, including in rural, urban, and under-resourced settings. Eligible applicants include universities, research institutions, and tribal and community organizations, but foreign (non-U.S.) organizations are not eligible to apply and foreign components are not allowed. A clinical trial is optional. It is aimed at research teams with mental-health services research expertise. No specific award amount is stated.

National Institutes of Health · Up to $500K

This NIH/National Cancer Institute R01 funds academic-industrial partnerships to translate and validate in vivo imaging, data science, or spectroscopic technologies into tools for cancer and other diseases; a clinical trial is optional. Eligible applicants include universities, research institutions, and tribal and community organizations, and foreign organizations are listed among eligible applicants. The award maximum is about $500,000, and the model assumes an academic-industry collaboration. It is aimed at research teams.

National Institutes of Health · Amount varies

This NIH/NHLBI R34 funds pilot studies that inform the planning of larger Phase II-IV clinical trials for heart, lung, blood, and sleep disorders; a clinical trial is optional. Eligible applicants include universities, research institutions, and tribal and community organizations; foreign organizations are not eligible to apply, though non-U.S. components of U.S. organizations are. It is a planning mechanism for research teams preparing larger trials. No specific award amount is stated.

Office of the Assistant Secretary for Health · $200K–$22M

This Title X program funds voluntary family planning services across U.S. states and territories. Eligible applicants are broad and include state, local, and tribal governments, public and private institutions of higher education, public housing authorities, and nonprofits with or without 501(c)(3) status. Awards are large, with individual amounts running into the millions and roughly $257 million expected across about 90 awards. The work must deliver clinical family planning services to low-income and uninsured populations, so applicants generally need health-service delivery capacity.

National Institutes of Health · Up to $350K

This NIH HEAL Initiative R61/R33 funds early translational drug-discovery research toward non-addictive pain therapeutics, including assay development, screening, and initial characterization of candidate agents; no clinical trial is allowed. Eligible applicants include universities, research institutions, and tribal and community organizations, but foreign organizations are not eligible to apply. The maximum award is about $350,000. It requires drug-discovery research capacity.

U.S. National Science Foundation · Amount varies

This NSF program funds Antarctic and Southern Ocean research that does not require U.S. Antarctic Program field support, including data/sample-based studies and analogue-site work. Eligibility is limited to U.S.-based nonprofit non-academic research organizations, institutions of higher education acting for their faculty, and federally recognized tribal nations. It is aimed at researchers and academic or research institutions. No specific award amount is stated.

National Institutes of Health · Amount varies

An NIH UE5/T32 award that funds federally recognized American Indian/Alaska Native Tribes, Tribal colleges, Tribal health programs, and Tribal organizations to build graduate-level research training in AI/AN health. Eligibility is restricted to qualifying Tribal entities; foreign organizations are not eligible. No award amount is specified. This is a narrow opportunity limited to Tribal applicants and is not a fit for other nonprofits, small businesses, or individuals.

Department of Housing and Urban Development · $112.5K–$250K

A HUD program providing one-time, cost-reimbursable grants for service coordination and limited direct services to residents of HUD-assisted housing facing emergencies such as natural disasters or public-health crises. Eligible applicants include public/Indian housing authorities, nonprofits (with or without 501(c)(3) status, including resident associations), multifamily owners, Tribal governments and entities, and faith-based organizations, so eligibility is relatively broad among housing-connected organizations. Awards run roughly $112,500 to $250,000. Note that funds are reimbursed after costs are incurred and serve HUD-assisted housing residents specifically.

National Institutes of Health · Amount varies

An NIH UE5/T34 award funding federally recognized American Indian/Alaska Native Tribes, Tribal colleges, Tribal health programs, and Tribal organizations to develop undergraduate-level research training in AI/AN health. Eligibility is restricted to qualifying Tribal entities; foreign organizations are not eligible. No award amount is specified. Like its T32 counterpart, this is narrow and not a fit for non-Tribal nonprofits, small businesses, or individuals.