Grants for State, Local & Tribal Governments

National Institutes of Health · Amount varies

This NIH/NINDS award (R61/R33) funds pharmacology and in vivo efficacy studies to advance candidate therapeutics for neurological and neuromuscular disorders toward further translational development. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, tribal governments, foreign organizations, and U.S. territories; it targets research organizations rather than individuals. No award amount is specified. The work is narrowly defined preclinical drug-development research.

National Institutes of Health · Up to $750K

This NIH/NINDS award (R61/R33) funds development and validation of animal models and tissue systems that mimic neurological and neuromuscular disorders to support future neurotherapeutic discovery; no clinical trial is allowed. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; it targets research organizations, not individuals. Awards run up to about $750,000. The model-development focus makes the scope narrow.

National Institutes of Health · Amount varies

This NIH/NIMH U01 funds individual research projects to discover and develop new drugs and neurostimulation approaches for mental disorders, substance use disorders, and alcohol use disorder. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; foreign organizations are not eligible, and it targets research organizations rather than individuals. No award amount is specified. The drug/device discovery focus makes the scope narrow.

National Institutes of Health · Amount varies

This NIH/NIMH U19 funds multi-project programs to discover and develop new drugs and neurostimulation approaches for mental disorders, substance use disorders, and alcohol use disorder. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; foreign organizations are not eligible, and it targets research organizations, not individuals. No award amount is specified. It supports large multidisciplinary programs, so the scope is narrow.

National Institutes of Health · Amount varies

This NIH/NCI R34 planning grant funds the design and preparation of cancer prevention and control clinical trials, covering screening, early detection, supportive care, and survivorship. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, tribal governments, foreign organizations, and U.S. territories; it targets research organizations, not individuals. No award amount is specified. It funds trial-planning activities rather than the trials themselves.

National Institutes of Health · Amount varies

This NIH/NCI U34 planning grant funds the design and preparation of cancer prevention and control clinical trials, including studies on screening, early detection, and survivorship. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, tribal governments, foreign organizations, and U.S. territories; it is aimed at research organizations, not individuals. No award amount is specified. It funds trial-planning work rather than the trials themselves, so review the scope carefully.

Dept of Environ Conservation · Up to $2M

This New York State Municipal Waste Reduction and Recycling Program (2024) funds governmental entities, not-for-profit organizations, and tribal organizations for waste reduction and recycling initiatives, with awards up to $2,000,000. Eligibility spans public, nonprofit, and tribal applicants. The deadline is November 1, 2027.

National Institutes of Health · Amount varies

This NIH/NIDDK R01 funds HIV/AIDS research aligned with NIDDK's mission and the NIH Office of AIDS Research priorities. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; it targets research organizations rather than individuals. No award amount is specified. Projects must fit the stated HIV/AIDS research priorities, so the scope is specific.

National Institutes of Health · Amount varies

This NIH/NINDS U01 is a limited competition open only to applicants holding existing NINDS-supported clinical trial cooperative agreement awards that need more time and resources to finish. Because it is restricted to current grantees, new applicants are not eligible; foreign organizations are also excluded. No award amount is specified. This opportunity does not apply to organizations that do not already hold the relevant NINDS award.

National Institutes of Health · Up to $1.5M

This NIH/NIA U01 funds preclinical and early (Phase I) clinical development of new drug candidates that aim to prevent, slow, or treat Alzheimer's disease. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; it targets research organizations, not individuals. Awards run up to about $1.5 million. Basic mechanism studies, repurposed drugs, and stand-alone clinical trials are out of scope, so the research focus is narrow.

National Institutes of Health · Amount varies

This NIH BRAIN Initiative R01 funds development of computational theories, models, and methods for analyzing complex brain-circuit data, to be shared with the research community. Eligible applicants are research organizations, including faith- or community-based organizations, tribal governments, foreign organizations, and U.S. territories; it targets institutions rather than individuals. No award amount is specified. The work is narrowly scoped to neural-circuit tool building, so confirm fit before applying.

National Institutes of Health · Up to $350K

This NIH/NIDA award funds research education programs that train clinicians and clinical researchers in substance use and substance use disorder research. Eligible applicants are research and education institutions, including HBCUs, Hispanic-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; it is aimed at organizations, not individuals. Awards run up to about $350,000. Note the program supports research education only, not non-research clinical training, so review the stated scope carefully.

National Institutes of Health · Amount varies

This NIH/NCI R01 funds advanced preclinical research translating nanotechnology-based cancer diagnostics and therapeutics toward later NCI translational programs; no clinical trial is allowed. Eligible applicants are research and education institutions, including minority-serving and tribal-serving institutions, faith- or community-based organizations, and tribal governments; it targets research organizations, not individuals. Foreign organizations are not eligible. No award amount is specified, and the nanomedicine focus makes the scope narrow.

Dept of the Army -- Materiel Command · Amount varies

This U.S. Army Research Laboratory Broad Agency Announcement solicits foundational (basic and applied) research proposals supporting Army modernization. Eligibility is broad, including universities, nonprofits, state and local governments, foreign organizations, and for-profit firms (large and small businesses). It uses a competitive merit-based process; no specific award amount is stated.

Environmental Protection Agency · Up to $3M

This EPA program funds assessment and remediation of contaminated Alaska Native Claims Settlement Act lands, plus related community outreach. Eligibility is limited to Alaska Native regional and village corporations, federally recognized Tribes in Alaska, Alaska Native nonprofit associations, and inter-tribal consortia of Alaskan tribal entities. The maximum award is up to about $3,000,000, and proposals are accepted on a rolling basis; applicants are asked to contact program managers first.

National Park Service · Amount varies

This National Park Service opportunity offers Master Cooperative Agreements to participants in the Cooperative Ecosystem Studies Units (CESU) network across listed regions, supporting research, technical assistance, education, and capacity building. Only existing CESU network partners may apply, so applicants must already have joined the network. No specific award amount is provided.

Community & Economic Development · Amount varies

Open broadly to Pennsylvania municipalities, local authorities, nonprofits, and other legal entities. Funded through the state's gaming-derived Sports Marketing and Tourism Account, it supports attracting amateur, professional, and e-sports events to the Commonwealth to boost tourism and economic impact. Award amount isn't specified; applications are due December 31, 2027.

Dept of the Army -- Materiel Command · Amount varies

This U.S. Army DEVCOM Analysis Center Broad Agency Announcement solicits applied-research proposals supporting Army modernization, tool development, and data curation. Eligibility is broad, including universities, nonprofits, state and local governments, foreign organizations, and for-profit firms (large and small businesses). It uses a whitepaper-then-proposal process; no specific award amount is stated.

National Institutes of Health · Up to $50K

The NIH parent Small Research Grant (R03, clinical trial not allowed) supports small, short-term projects such as pilot and feasibility studies, secondary data analysis, and methodology development. A broad range of domestic and foreign institutions may apply, including universities, tribal governments, and community-based organizations. The award is capped at about $50,000. The small budget suits research institutions pursuing limited-scope projects to generate preliminary data.

National Institutes of Health · Amount varies

An NIH research project grant (R01, clinical trials optional) supporting population-based research on how work and occupation influence health outcomes among populations with health disparities. Eligible applicants are domestic institutions such as universities, tribal governments, and community-based organizations; foreign organizations, foreign components of U.S. organizations, and foreign components are not eligible. No specific award amount is stated. This suits research institutions conducting population health-disparities research.