Grants for Small Businesses

Food and Drug Administration · $225K–$2.5M

This FDA grant (U18, $225,000 to $2,500,000) funds veterinary diagnostic laboratories in the Vet-LIRN network to build capacity for animal food safety and antimicrobial resistance testing, including equipment and method development. Eligibility is broad, covering nonprofits (with or without 501(c)(3) status), small businesses, for-profit organizations, universities, tribal governments, and state/local governments. No unusual disqualifiers are noted, and the deadline is not imminent.

National Institutes of Health · Amount varies

This NIH HEAL Initiative UG3/UH3 cooperative agreement funds preclinical optimization and development of safe, non-addictive small-molecule and biologic therapeutics for treating pain, advancing candidates toward Phase II trials. Applicants must already have a promising lead candidate, a strong biological rationale, and established assays. Foreign organizations and foreign components of U.S. organizations are not eligible to apply.

Fish and Wildlife Service · Amount varies

The U.S. Fish and Wildlife Service offers Cooperative Agriculture Agreements that let private individuals or small businesses farm, hay, or graze on National Wildlife Refuge lands in support of conservation objectives. This is a non-financial program: no federal funds are awarded, and arrangements are cost-sharing or in-kind (labor, equipment, crop yield) and may involve bids or payments to the Service. Pre-application coordination is required, and only private individuals or small business entities are eligible.

Dept of the Army -- Materiel Command · Amount varies

The Army Applications Lab Broad Agency Announcement funds basic and applied scientific research in defense-relevant areas described in the BAA. Eligibility is unusually broad: institutions of higher education, nonprofits, state and local governments, foreign organizations and public entities, and for-profit businesses (large and small) may all apply. No specific award amount is listed, and projects are selected through full and open competition, so applicants should review the BAA's stated research areas of interest.

National Institutes of Health · Amount varies

This NIH SBIR Phase IIB award is restricted to U.S. small business concerns that have previously received an NIH SBIR or STTR Phase II award; it bridges the gap between Phase II and commercialization for later-stage R&D. Only one such award is allowed per project, and applications must be submitted within the first six due dates after the Phase II budget period ends, so it is narrow and limited to existing grantees. Foreign organizations are not eligible to apply.

National Institutes of Health · Amount varies

This NIH SBIR/STTR Commercialization Readiness Pilot (CRP) is restricted to U.S. small business concerns (as defined by the SBA) and helps move NIH-funded SBIR/STTR projects from late-stage development toward commercialization. It supports later-stage R&D and technical assistance such as replication studies, IND/IDE-enabling work, clinical studies, manufacturing scale-up, and regulatory support, and a significant portion may be subcontracted. Foreign organizations are not eligible to apply.

Advanced Research Projects Agency Energy · $5M–$20M

ARPA-E's SCALEUP READY program funds the scale-up of promising clean and advanced energy technologies, with awards in the range of roughly $5 million to $20 million. It targets organizations developing transformative energy technologies aimed at improving U.S. energy security, efficiency, and emissions. Specific eligibility is set out in the NOFO (Section II.A.) available on the ARPA-E eXCHANGE site; applications must be submitted through that portal rather than Grants.gov, and cost-share is typical for ARPA-E awards, so review the NOFO before applying.

National Institute of Standards and Technology · From $10M

This NIST CHIPS R&D Office Broad Agency Announcement funds research, prototyping, and commercial solutions that advance U.S. microelectronics technology, with a stated floor of about $10 million per award. Eligible applicants include for-profit and non-profit organizations, accredited universities, FFRDCs, and federal entities, but they must be domestic; individuals and unincorporated sole proprietors are not eligible. Some foreign partners may participate as subawardees, subject to restrictions (foreign adversaries excluded). Given the large award size, applicants should review the full BAA for compliance requirements.

Munitions Directorate · Up to $750M

This Air Force (Munitions Directorate) Broad Agency Announcement funds research and development supporting air dominance, with a program ceiling reported up to roughly $750 million. Eligibility is described as unrestricted and open to any type of entity, subject to any clarifications in the full announcement, making it broadly accessible to businesses, universities, and nonprofits. Because it is defense-focused R&D, applicants should expect security and compliance requirements and should review the full BAA for specifics.

ACC APG - Natick · Amount varies

This Army Broad Agency Announcement funds scientific research and development in areas like combat feeding, soldier protection, human performance, and battlefield technology. It is open to colleges/universities, nonprofit research institutes, foreign organizations, and commercial firms of all sizes (including small and veteran-owned businesses), but government facilities and organizations are explicitly excluded from consideration. No specific award amount is listed, and the deadline is not near-term (2030).

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-IP-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. The entry is a placeholder for Type 6 (continuation/competing renewal) applications and does not state award amounts or program specifics. Because it appears aimed at existing grantees, check with CDC about eligibility if you have not held a prior award.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-OE-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. It is listed only as a placeholder for Type 6 (continuation/competing renewal) applications, with no award amounts or detailed requirements. Since it appears intended for existing grantees, confirm eligibility with CDC before applying as a new applicant.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-DD-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. It is a placeholder listing for renewal-type applications and provides no award amounts or detailed program requirements. As it appears geared toward existing grantees, confirm eligibility with CDC before applying as a new applicant.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-DP-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. The entry is a placeholder for Type 6 (continuation/competing renewal) applications and does not list award amounts or program details. As it appears geared toward existing grantees, check with CDC about eligibility before applying as a new organization.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-EH-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. It is a placeholder for Type 6 (continuation/competing renewal) applications, with no stated award amounts or detailed requirements. Because it appears aimed at existing grantees, confirm eligibility with CDC if you are a first-time applicant.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-TP-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. The entry is a placeholder for Type 6 (continuation/competing renewal) applications and does not list award amounts or program details. Since it appears intended for existing grantees, check with CDC about eligibility before applying as a new organization.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-CD-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. It is a placeholder for Type 6 (continuation/competing renewal) applications, with no stated award amounts or specific requirements. Because it appears aimed at existing grantees, confirm eligibility with CDC if you are a first-time applicant.

Centers for Disease Control and Prevention - ERA · Amount varies

This is a CDC health research opportunity (RFA-CE-18-000) open to a broad range of applicants, including states, universities, counties, small businesses, and nonprofit organizations. It is described only as a placeholder for Type 6 (continuation/competing renewal) applications, so funding amounts and specific program details are not stated. Because it appears geared toward existing grantees submitting renewal-type applications, confirm with CDC whether new applicants are eligible before applying.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-CC-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. The listing is a placeholder for Type 6 (continuation/competing renewal) applications and gives no award amounts or program details. As it appears geared toward existing grantees, verify with CDC whether new organizations can apply.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-CK-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. It is listed only as a placeholder for Type 6 (continuation/competing renewal) applications, with no award amounts or specific requirements provided. Because it appears intended for existing grantees, confirm with CDC whether new applicants can apply.