Grants for Small Businesses

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-TS-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. The listing is a placeholder for Type 6 (continuation/competing renewal) applications and does not state award amounts or detailed program requirements. Since it appears aimed at existing grantees filing renewal-type applications, verify eligibility with CDC if you are a first-time applicant.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-SH-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. It is a placeholder for Type 6 (continuation/competing renewal) applications, with no award amounts or detailed requirements listed. As it appears geared toward existing grantees, confirm eligibility with CDC before applying as a new organization.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-PS-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. The listing is a placeholder for Type 6 (continuation/competing renewal) applications and provides no award amounts or specific program details. Since it appears intended for existing grantees, verify with CDC whether new applicants are eligible.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC global health research opportunity (RFA-GH-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. The listing is a placeholder with minimal detail and no stated award amounts. Because such CDC RFA placeholders are typically used for renewal-type applications, verify with CDC whether new applicants are eligible and what the actual program scope is.

Centers for Disease Control and Prevention - ERA · Amount varies

This CDC health research opportunity (RFA-OT-18-000) is open to states, universities, counties, small businesses, and nonprofit organizations. It is listed as a placeholder for Type 6 (continuation/competing renewal) applications, with no award amounts or specific requirements provided. Since it appears intended for existing grantees, confirm eligibility with CDC before applying as a new organization.

Defense Threat Reduction Agency · Amount varies

The Defense Threat Reduction Agency's Fundamental Research BAA solicits basic research to counter weapons of mass destruction, using a white-paper-first (pre-application) process. Full eligibility is set out in Section 3 of the BAA, which for this type of defense research announcement typically includes universities, nonprofit research institutes, and businesses, but you should review the BAA directly to confirm. Award amounts are not listed here; note that pre-application white papers for the newly added Topics B1-B6 were due March 2, 2026, so check current topic deadlines before preparing a submission.

Community & Economic Development · Amount varies

This Pennsylvania Enterprise Zone Tax Credit provides tax incentives to businesses and private for-profit companies that invest in rehabilitating, expanding, or improving buildings or land within designated enterprise zones. Nonprofits are not listed as eligible applicants for this particular program, unlike other Neighborhood Assistance Program tracks. No funding amount is specified, and the deadline is far out.

Community & Economic Development · Amount varies

This Pennsylvania tourism program funds marketing and event-attraction efforts (destination marketing, sports events, major concerts/conventions) to draw visitors to Pennsylvania, open to destination marketing organizations, tourism-related businesses, and regional/industry coalitions. Eligibility differs by sub-program (e.g., some events must draw multi-night stays), so applicants should confirm which track fits their project. No funding amount is specified, and the deadline is far out.

Community & Economic Development · Amount varies

The Video Game Production Tax Credit is a Pennsylvania state tax credit available only to video game production companies operating in the Commonwealth. It is not a cash grant but a credit against state tax liability, and eligibility is restricted to this single, narrow industry category. No award amount is specified.

Community & Economic Development · Amount varies

Eligible applicants are businesses, municipalities, economic development organizations, redevelopment/industrial development authorities, and other for-profit entities involved in site development — general nonprofits and individuals are not the intended audience. It provides grants and loans as gap financing to make strategic sites in Pennsylvania construction-ready for businesses that are relocating or expanding. No specific award amount or deadline is listed.

Community & Economic Development · Amount varies

The PEDFA Taxable Bond Program gives Pennsylvania businesses and 501(c)(3) nonprofits access to low-interest financing through taxable bonds or notes, targeted at manufacturing, solid waste disposal, wastewater treatment, transportation facilities, and assisted living/housing projects. This is debt financing rather than a grant, and eligibility is limited to these specific project types and organization categories. No award amount is specified.

Community & Economic Development · Amount varies

The Keystone Special Development Zone Tax Credit provides Pennsylvania tax credit incentives to for-profit businesses that locate and operate within designated geographic zones containing abandoned or deteriorated industrial and commercial sites. Only for-profit businesses within these specific zones qualify; nonprofits and businesses elsewhere are not eligible. No award amount is specified since this is a tax credit rather than a grant.

Community & Economic Development · Amount varies

The Qualified Manufacturing Innovation and Reinvestment Deduction is a Pennsylvania tax deduction, not a grant — it reduces state tax liability for employers investing in manufacturing operations. Eligibility is limited to businesses that are employers, not nonprofits or individuals. No award/deduction amount is specified.

Community & Economic Development · Amount varies

The PA SITES Construction Loan component provides gap financing grants and loans for strategic site development projects in Pennsylvania, aimed at reducing costs and risk for businesses relocating or expanding in the state. Eligible applicants include municipalities, economic development organizations, redevelopment or municipal authorities, industrial development agencies, and for-profit businesses. No maximum award amount is specified, and general nonprofits or individuals do not qualify.

Community & Economic Development · Amount varies

The Opportunity Scholarship Tax Credit gives Pennsylvania-authorized businesses a state tax credit for contributions to Opportunity Scholarship Organizations, which then fund tuition scholarships for students in low-achieving school districts. Only businesses can apply (not individuals or nonprofits directly), and applications follow specific windows tied to prior commitment status. No award dollar cap is specified for the credit itself.

Community & Economic Development · Amount varies

This Pennsylvania program funds environmental site assessment and cleanup of former industrial sites through a mix of grants and low-interest loans. Eligible applicants include public entities, private nonprofit economic development organizations, and companies reusing former industrial land, but only if they did not cause or contribute to the contamination. No maximum award is listed.

Community & Economic Development · Amount varies

The Pennsylvania First Grant is a broad economic development funding tool supporting job creation and business investment, open to businesses, corporations, partnerships, sole proprietorships, LLCs, nonprofit entities, and a wide range of municipalities and local development authorities. Eligibility spans both for-profit and nonprofit organizations as well as many types of local government, making this one of the broader-eligibility programs in this set. No specific award amount is listed.

Community & Economic Development · Amount varies

Eligibility is limited to businesses that commit to creating and retaining full-time jobs, and to organizations developing industrial parks or multi-tenant facilities. This is a loan and line-of-credit program, not a grant, and applications must be packaged and underwritten through a certified economic development organization (CEDO) rather than submitted directly by the applicant. No specific loan amount or deadline is listed.

Community & Economic Development · Amount varies

The Pipeline Investment Program funds construction of the final stretch of natural gas distribution lines connecting business parks and existing manufacturing or industrial sites in Pennsylvania to gas service. Eligible applicants include economic development organizations, businesses, municipalities, hospitals, and school districts. No award amount is specified, and the program is narrowly scoped to natural gas infrastructure projects.

Community & Economic Development · Amount varies

The PA SITES Planning Grant funds feasibility studies and site plans to prepare Pennsylvania properties for future business development or redevelopment. Eligible applicants are municipalities, economic development organizations, redevelopment or municipal authorities, industrial development agencies, and for-profit businesses. No specific award amount is listed, and eligibility excludes general nonprofits and individuals outside these categories.