HeartShare 2.0: Refining Heart Failure Subtypes and Treatment Targets for Personalized Clinical Trials - Clinical Trial Center and Clinical Centers (U01 Clinical Trial Optional)

National Institutes of HealthUp to $500,000Closed

Researchers Schools & universities Large award Narrow eligibility

Deadline: Jul 9, 2026
Posted: May 19, 2026
Award amount: Up to $500,000
Focus areas: Health

In plain English

This NIH (NHLBI) opportunity funds a Clinical Trial Center and up to seven Clinical Centers for the HeartShare 2.0 program, which conducts deep phenotyping and precision clinical trials in heart failure with preserved ejection fraction. It targets U.S. research institutions; foreign organizations cannot apply, though foreign components and non-U.S. components of U.S. organizations are allowed. Applicants may apply for the CTC or a CC (with different PIs). Awards go up to about $500,000.

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Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

About this grant

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for a new Clinical Trial Center (CTC) and up to seven Clinical Centers (CCs) for the HeartShare 2.0 program. The CTC will coordinate precision clinical trial activities focused on heart failure with preserved ejection fraction (HFpEF), including master protocol development, project management, recruitment oversight, performance milestones, and scientific conduct of trials. The CCs will recruit and retain heart failure patients and controls. The CCs will participate in all aspects of conducting a deep phenotyping protocol and longitudinal follow-up of HFpEF patients; obtaining tissue biopsies; and recruiting patients for future clinical trials.Eligible applicants may submit proposals for either the CTC or CC, but must have different PIs. Each application should include CTC or CC as part of their project title.Companion NOFO for RFA-HL-27-009 will support a Data Translation Center (DTC) for overall coordination of the HeartShare program.

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