Grants for Nonprofits

National Institutes of Health · Amount varies

Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH R61/R33 funds milestone-driven development of clinical trials to treat co-occurring health conditions in people with Down syndrome — up to two years of planning followed by up to three years of trial support. Clinical trials are required.

National Institutes of Health · Up to $200K

Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH R21 funds exploratory, higher-risk Down syndrome research — feasibility studies, novel methods, or new applications of existing techniques. Awards up to about $200,000.

National Institutes of Health · Amount varies

Open to U.S. universities, research institutions, nonprofits, and certain government/tribal organizations; foreign organizations are not eligible. This NIH R21 funds projects that improve clinical-trial readiness for rare diseases — developing biomarkers and outcome measures, or characterizing a disease's course to enable future trials. Award size follows standard R21 limits.

Defense Health Agency Contracting Activity - DHACA · $750K–$50M

Open broadly to any type of entity — universities, nonprofits, businesses (including small businesses), and others. This Department of Defense / Defense Health Agency broad agency announcement funds extramural biomedical and human-performance research and development through FY28. Awards span a very wide range, from about $750,000 to $50 million.

National Institutes of Health · Up to $3M

Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH UG3/UH3 funds discovery and development of interventions — medications and devices — to prevent and treat substance use disorders and overdose, including preclinical and clinical studies. Awards up to about $3,000,000.

National Institutes of Health · Up to $500K

Open to U.S. universities, research institutions, nonprofits, and certain government/tribal organizations; foreign organizations are not eligible. This NIH R01 funds development of non-invasive or minimally invasive technologies to image the human olfactory system at high resolution. Awards up to about $500,000; multidisciplinary teams are encouraged.

National Institutes of Health · Amount varies

Open to U.S. universities, research institutions, nonprofits, and certain government/tribal organizations; foreign organizations are not eligible. This NIH R01 supports early-stage investigators pursuing a new research direction, and applications must include no preliminary data. Award size follows standard R01 limits; aimed at researchers early in their independent careers.

Food and Drug Administration · $225K–$2.5M

Open to veterinary diagnostic laboratories in the FDA Vet-LIRN network, including 501(c)(3) and other nonprofits, public and private universities, state/local/tribal governments, small businesses, and other for-profits; participation in the Vet-LIRN network is required. This FDA U18 funds projects and equipment to develop or validate testing methods for animal food safety and antimicrobial resistance, short-term surveillance, antimicrobial stewardship, and One Health work. Awards range from about $225,000 to $2.5 million.

National Institutes of Health · Amount varies

Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH/NCI R21 funds early-stage, exploratory research on cancer control — prevention behaviors, screening, etiology, and novel methods. Award size follows standard R21 limits.

National Institutes of Health · Amount varies

Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH DP1 (Avant-Garde/Avenir) funds high-risk, high-reward research on HIV and substance use — basic, clinical, translational, or implementation science. It backs bold, transformative ideas; award size follows the DP1 mechanism.

National Institutes of Health · Up to $400K

This NIH R01 grant funds research into early immune system development from the prenatal period through early childhood, including effects of in-utero HIV or antiretroviral exposure. A broad range of applicants is eligible, including colleges and universities, tribal governments, faith- and community-based organizations, minority-serving institutions, and foreign organizations. The award ceiling is up to about $400,000.

National Institutes of Health · Up to $300K

This NIH UG3/UH3 cooperative agreement funds community-based participatory research that tests population-level interventions to improve oral health by addressing social and chronic-disease risk factors through cross-sector community partnerships. The award ceiling is up to about $300,000. Foreign organizations and foreign components of U.S. organizations are not eligible to apply, and foreign components are not allowed.

U.S. National Science Foundation · $1.5M–$6.5M

This National Science Foundation program funds Mathematical Sciences Research Institutes as national resources that advance research in mathematics and statistics and broaden participation, with awards ranging roughly from $1.5 million to $6.5 million. Only U.S.-based non-profit non-academic research organizations and accredited institutions of higher education may apply; multi-institutional consortia are allowed but one entity must take overall management responsibility. Individuals and for-profit firms are not eligible.

Dept of the Army -- Materiel Command · Amount varies

The Army Applications Lab Broad Agency Announcement funds basic and applied scientific research in defense-relevant areas described in the BAA. Eligibility is unusually broad: institutions of higher education, nonprofits, state and local governments, foreign organizations and public entities, and for-profit businesses (large and small) may all apply. No specific award amount is listed, and projects are selected through full and open competition, so applicants should review the BAA's stated research areas of interest.

National Institutes of Health · Amount varies

The NIH Science Education Partnership Award (SEPA, R25) funds educational projects that increase understanding of biomedical research among pre-college (pre-K through grade 12) students and encourage interest in STEM careers. It suits universities, research institutions, and education-focused organizations that can run science education programs. Only domestic U.S. organizations may apply; foreign organizations are not eligible and foreign components are not allowed. Clinical trials are not permitted.

National Institute of Standards and Technology · From $10M

This NIST CHIPS R&D Office Broad Agency Announcement funds research, prototyping, and commercial solutions that advance U.S. microelectronics technology, with a stated floor of about $10 million per award. Eligible applicants include for-profit and non-profit organizations, accredited universities, FFRDCs, and federal entities, but they must be domestic; individuals and unincorporated sole proprietors are not eligible. Some foreign partners may participate as subawardees, subject to restrictions (foreign adversaries excluded). Given the large award size, applicants should review the full BAA for compliance requirements.

Munitions Directorate · Up to $750M

This Air Force (Munitions Directorate) Broad Agency Announcement funds research and development supporting air dominance, with a program ceiling reported up to roughly $750 million. Eligibility is described as unrestricted and open to any type of entity, subject to any clarifications in the full announcement, making it broadly accessible to businesses, universities, and nonprofits. Because it is defense-focused R&D, applicants should expect security and compliance requirements and should review the full BAA for specifics.

Naval Supply Systems Command · $0

This Naval Postgraduate School opportunity funds basic and applied STEM research (not hardware procurement or development of a specific system). Eligible applicants are public and private institutions of higher education and 501(c)(3) nonprofits other than universities, so it is restricted to academic and nonprofit research organizations. Applicants are encouraged to first submit a white paper to NPS for feedback before submitting a full proposal through Grants.gov. No award amount is specified.

ACC APG - Natick · Amount varies

The DEVCOM Soldier Center's Broad Agency Announcement seeks scientific research and exploratory development in areas such as soldier protection, combat feeding, human performance, modeling and simulation, and training technology. Eligible applicants include degree-granting colleges and universities, nonprofit research institutes, foreign organizations, and commercial firms of all sizes (including small and disadvantaged businesses); proposals from government facilities will not be considered. Award amounts are not specified, and submission details are in the full BAA on SAM.gov.

Centers for Disease Control and Prevention - ERA · $0

This is a CDC health research opportunity (RFA-CE-18-000) open to a broad range of applicants, including states, universities, counties, small businesses, and nonprofit organizations. It is described only as a placeholder for Type 6 (continuation/competing renewal) applications, so funding amounts and specific program details are not stated. Because it appears geared toward existing grantees submitting renewal-type applications, confirm with CDC whether new applicants are eligible before applying.