Grants for Nonprofits

National Institutes of Health · Amount varies

Open to a broad range of applicants including universities, minority-serving institutions, tribal governments, faith- and community-based organizations, foreign organizations, and individuals or businesses developing their own devices under this NIH Blueprint MedTech UG3/UH3 (clinical trial optional). Funds translational and clinical-feasibility work to develop therapeutic and diagnostic devices for nervous-system and neuromuscular disorders, with access to NIH-funded consultants and contract research organizations. It is a milestone-driven cooperative agreement with NIH staff involvement; no specific award amount is listed.

Centers for Disease Control and Prevention - ERA · $250K–$975K

A CDC/NIOSH and Coast Guard training grant (T03) to develop and deliver safety training for U.S. commercial fishermen. Eligible applicants include school districts, public/Indian housing authorities, Native American tribal organizations, faith- or community-based organizations, regional organizations, bona fide state agents, and FFRDCs. Awards range from about $250,000 to $975,000. Eligibility is moderately broad across organizations but excludes individuals; review the listed categories to confirm fit.

Centers for Disease Control and Prevention - ERA · $150K–$975K

Open to universities and researchers, nonprofits, businesses (including small businesses), and individuals with expertise in commercial fishing and maritime safety. Funds research to improve worker safety in commercial fishing — vessel design, survival and emergency equipment, monitoring and communication systems. Awards run roughly $150,000–$975,000, administered by CDC/NIOSH.

Washington Headquarters Services · $100K–$10M

Open to industry, nonprofits, colleges and universities, and state or local educational agencies; foreign entities are not eligible. An ongoing 'open' announcement funding STEM education, outreach, and workforce-development programs for the Department of War's research enterprise, with specific topics released as amendments (often beginning with a white paper). Awards range widely, from about $100,000 to $10 million.

Food and Drug Administration · $0–$600K

Open very broadly to universities, nonprofits (with or without 501(c)(3) status), for-profit and small businesses, state/local/tribal governments, and foreign organizations under this FDA R01 (clinical trial optional). Funds efficient, innovative natural history studies that advance medical product development for rare diseases with unmet needs, generating high-quality data to address knowledge gaps. Awards reach roughly $600,000.

Bureau of Reclamation · $50K–$300K

Open to watershed groups — and the states, tribes, local governments, special districts, nonprofits, or universities that sponsor them — located in 19 western states and several U.S. territories. Federal entities and individuals cannot apply. Funds forming watershed groups and planning watershed-restoration and water-management projects, with awards of about $50,000–$300,000. Eligibility is narrow: you must be or sponsor a qualifying watershed group in an eligible state.

National Institutes of Health · Amount varies

Open to U.S. universities, research institutions, nonprofits, and certain government and tribal organizations; foreign organizations are not eligible. This NIH R21 funds exploratory, early-stage projects developing methods or agents to target 'undruggable' molecules in serious diseases. Award size isn't specified and follows standard NIH R21 limits; best suited to researchers pursuing high-risk, innovative therapeutics.

National Institutes of Health · Amount varies

Open to U.S. research and community organizations, tribal governments, faith- and community-based groups, and territories, but foreign organizations and foreign components are not eligible. This NIH X01 resource-access award grants approved investigators access to limited identifiable data and biospecimens from the ECHO maternal and child health cohort to study high-priority maternal and child health questions. No clinical trial is allowed and no funding amount is provided, since the award provides data/specimen access rather than research dollars.

Dept of the Army -- Materiel Command · Amount varies

Open to higher-education institutions, nonprofits, and for-profit organizations, domestic or foreign (security restrictions may limit foreign participants; government labs, FFRDCs, and service academies can't be prime applicants). This Army Research Institute broad agency announcement funds basic, applied, and advanced research in the behavioral and social sciences tied to soldier performance and readiness. Applicants are encouraged to contact the listed technical point of contact first; funding varies by budget cycle.

DOC NOAA - ERA Production · $15K–$75K

Open to individuals (as legal entities), commercial organizations, state/local/tribal governments, universities, and nonprofits; federal agencies and employees can't apply, and projects must be conducted in Alaska. Funds marine workforce training, seafood-safety and management education, fishing innovation, and consumer outreach. Awards are small, roughly $15,000–$75,000.

National Institutes of Health · Amount varies

Open to domestic research and education organizations including universities, minority-serving institutions, tribal governments, and faith- and community-based groups under this NIH T32 institutional training grant; foreign institutions and foreign components are not eligible to apply. Funds institutions to run predoctoral and postdoctoral research training programs (including short-term training) that build the biomedical, behavioral, and clinical research workforce. Appointed trainees may not lead an independent clinical trial; no specific award amount is listed.

National Institutes of Health · Up to $500K

Open to U.S. schools and colleges of nursing and other research institutions, nonprofits, and certain government/tribal organizations; foreign organizations are not eligible. This NIH P20 funds new research centers that build nursing-led, community-partnered research infrastructure and pilot studies. Awards up to about $500,000.

National Institutes of Health · Amount varies

Open to domestic institutions — universities, research institutions, nonprofits, and certain government/tribal organizations (foreign institutions are not eligible). This NIH T35 funds short-term (often summer) research-training experiences for health-professional and graduate students. It supports the institution's training program rather than an individual.

National Institutes of Health · Up to $1M

Open to U.S. universities, research institutions, nonprofits, foreign organizations, and certain government/tribal entities. This NIH R01 funds preclinical mouse-model testing of repurposed or investigational drugs — alone or with non-drug interventions — for Alzheimer's disease and related dementias. Awards up to about $1,000,000.

National Institutes of Health · Amount varies

Open to U.S. universities, research institutions, nonprofits, foreign organizations, and certain government/tribal entities. This NIH X01 provides access to TOPMed genomic and multi-omics data resources to study heart, lung, blood, and sleep disorders — it offers data generation, not direct funding. Aimed at researchers doing functional-genomics and mechanism studies.

Food and Drug Administration · $0–$900K

Open to nearly any organization — universities, nonprofits (with or without 501(c)(3)), for-profits and small businesses, state/local/tribal governments, and foreign organizations. This FDA R01 funds clinical trials of orphan products evaluating safety and efficacy to address unmet needs in rare diseases. Awards up to about $900,000; clinical trials are required.

National Institutes of Health · Up to $2.1M

Open to U.S. research institutions and universities, nonprofits, and certain government/tribal organizations; foreign organizations cannot apply, and (as of May 2025) projects with foreign subawards are ineligible. This NIH U2C-TL1 funds institutional networks that recruit and train researchers in kidney, urologic, and hematologic disease research. Awards up to about $2,100,000.

National Institutes of Health · Amount varies

Open to eligible NIGMS-funded investigators and new investigators at U.S. institutions; foreign organizations are not eligible, and projects with foreign subawards are excluded. This NIH R35 (MIRA) gives an investigator stable, flexible single-grant support for their lab's research within the NIGMS mission, rather than project-by-project funding. Early-stage investigators should use the separate ESI MIRA notice.

National Institutes of Health · Amount varies

Open to U.S. universities, research institutions, nonprofits, and certain government/tribal organizations; foreign organizations are not eligible. This NIH R61/R33 funds mechanistic clinical research on how mind-and-body interventions (e.g., meditation, yoga, acupuncture) affect emotional well-being and whole-person health, in two milestone-tied phases. Strong preliminary data are expected.

National Institutes of Health · Up to $500K

Open to U.S. and foreign research institutions, universities, nonprofits, and certain government/tribal organizations. This NIH R01 funds groundbreaking, high-impact Down syndrome research across any relevant topic, with no preliminary data required. Awards up to about $500,000.